(+/-)-Noformicin | 16426-41-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-Noformicin
• 英文别名: 5-amino-N-(3-amino-3-iminopropyl)-3,4-dihydro-2H-pyrrole-2-carboxamide
• CAS: 16426-41-8；155-38-4
• 化学式: C₈H₁₅N₅O
• 分子量: 197.24
• InChiKey: QGFXBZOMUMWGII-UHFFFAOYSA-N

物化性质

• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Novel derivatives of carnosic acid
  申请人：——

  公开号：US20040014808A1

  公开（公告）日：2004-01-22

  Incubations with Nocardia sp., NRRL 5646 were conducted to produce new derivatives of the abietane-diterpene chemoprotectant and antioxidant, carnosic acid. Reduction of the C-20 carboxylic acid functional group followed by methylation at the C-12 phenol afforded the novel compound 11,20-dihydroxy-12-methoxy-abiet-8,11,13-triene. Oxidative cyclization of carnosic acid to carnosol followed by dihydroxylation at the isopropyl moiety afforded the novel compound 11,12,16,17-tetrahydroxy-7-10-(epoxymethano)-abiet-8,11,13-triene-20-one. The metabolites are new carnosic acid derivatives whose structures were confirmed by mass spectrometry and NMR spectroscopic analysis. The radical quenching properties of the new metabolites using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging assay showed activities improved over that of mixed tocopherols and carnosic acid.

  使用Nocardia sp.，NRRL 5646进行孵育，以产生新的阿比特烷二萜化学保护剂和抗氧化剂卡诺酸的衍生物。将C-20羧酸官能团还原，然后在C-12酚上进行甲基化，得到新化合物11,20-二羟基-12-甲氧基-阿比-8,11,13-三烯。将卡诺酸氧化环化为卡诺索，然后在异丙基部分进行二羟基化，得到新化合物11,12,16,17-四羟基-7-10-(环氧甲氧基)-阿比-8,11,13-三烯-20-酮。通过质谱和核磁共振光谱分析确认了这些新卡诺酸衍生物的结构。利用2,2-二苯基-1-苯基肼基自由基清除试验显示，新代谢产物的自由基清除性能优于混合生育酚和卡诺酸。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Sequence-directed DNA-binding molecules compositons and methods
  申请人：Genelabs Technologies, Inc.

  公开号：US20030124530A1

  公开（公告）日：2003-07-03

  The present invention defines a DNA: protein-binding assay useful for screening libraries of synthetic or biological compounds for their ability to bind DNA test sequences. The assay is versatile in that any number of test sequences can be tested by placing the test sequence adjacent to a defined protein binding screening sequence. Binding of molecules to these test sequence changes the binding characteristics of the protein molecule to its cognate binding sequence. When such a molecule binds the test sequence the equilibrium of the DNA:protein complexes is disturbed, generating changes in the concentration of free DNA probe. Numerous exemplary target test sequences (SEQ ID NO:1 to SEQ ID NO:600) are set forth. The assay of the present invention is also useful to characterize the preferred binding sequences of any selected DNA-binding molecule.

  本发明定义了一种 DNA：蛋白质结合测定法，可用于筛选合成或生物化合物库，以确定其结合 DNA 测试序列的能力。这种检测方法用途广泛，只要将检测序列与确定的蛋白质结合筛选序列相邻，就可以检测任何数量的检测序列。分子与这些测试序列的结合会改变蛋白质分子与其同源结合序列的结合特性。当这种分子与测试序列结合时，DNA：蛋白质复合物的平衡就会被打破，从而引起游离 DNA 探针浓度的变化。这里列出了许多示例性的目标测试序列（SEQ ID NO:1 至 SEQ ID NO:600）。本发明的检测方法也可用于鉴定任何选定 DNA 结合分子的优选结合序列。
• Nucleic acid-binding polymers
  申请人：Veridian Systems Division

  公开号：US20040157217A1

  公开（公告）日：2004-08-12

  The present invention relates to a nucleic acid binding polymer which has affinity for nucleic acid molecules such as DNA, RNA, or hybrids thereof. The polymer is comprised of a nucleic acid binding backbone linked to a nucleic acid binding agent, preferably by a linking moiety. The polymer can be used to isolate and purify nucleic acid molecules from a variety of sample types including but not limited to clinical and environmental.

  本发明涉及一种核酸结合聚合物，它对 DNA、RNA 或其混合物等核酸分子具有亲和力。 该聚合物由核酸结合骨架和核酸结合剂（最好是连接分子）组成。 该聚合物可用于从各种类型的样本中分离和纯化核酸分子，包括但不限于临床样本和环境样本。
• EP0684999A4
  申请人：——

  公开号：EP0684999A4

  公开（公告）日：1997-05-07