3-hydroxybutanoyl CoA

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-hydroxybutanoyl CoA
• 英文别名: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxybutanethioate
• 化学式: C₂₅H₄₂N₇O₁₈P₃S
• 分子量: 853.6
• InChiKey: QHHKKMYHDBRONY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  54
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  409
• 氢给体数：
  10
• 氢受体数：
  23

文献信息

• LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
  申请人：Tang Yi

  公开号：US20120190038A1

  公开（公告）日：2012-07-26

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
• RECOMBINANT MICROORGANISMS WITH 1,3-BUTANEDIOL-PRODUCING FUNCTION AND USES THEREOF
  申请人：Okabayashi Tomohito

  公开号：US20120276606A1

  公开（公告）日：2012-11-01

  An objective of the present invention is to provide recombinant microorganisms efficiently producing optically active 1,3-butanediol, which is useful as a material for synthesizing pharmaceuticals and such, and provide methods for efficiently producing optically active 1,3-butanediol using the recombinant microorganisms. As a result of dedicated research for achieving the above objective, the present inventors succeeded in producing recombinant microorganisms in which the activity of an enzyme catalyzing the reduction reaction represented by Formula 1 is enhanced and which produce a diol compound represented by Formula 2. (wherein R represents a C 1-3 alkyl group or hydrogen) (wherein R represents a C 1-3 alkyl group or hydrogen)
• METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS
  申请人：Tang Yi

  公开号：US20120315680A1

  公开（公告）日：2012-12-13

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
• Process For Preparing Hyperpolarized Substrates And Method For MRI
  申请人：Aime Silvio

  公开号：US20130096420A1

  公开（公告）日：2013-04-18

  The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
• VARIANT LovD POLYPEPTIDE
  申请人：The Regents of the University of California

  公开号：US20150218531A1

  公开（公告）日：2015-08-06

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.