5,6-二羟基吡嗪-2,3-二羧酸 | 58084-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5,6-二羟基吡嗪-2,3-二羧酸
• 英文名称: 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylic acid
• 英文别名: 5,6-dioxo-1,4,5,6-tetrahydro-pyrazine-2,3-dicarboxylic acid；5,6-Dioxo-1,4,5,6-tetrahydro-pyrazin-2,3-dicarbonsaeure；5,6-Dihydroxypyrazine-2,3-dicarboxylic acid；5,6-dioxo-1,4-dihydropyrazine-2,3-dicarboxylic acid
• CAS: 58084-27-8
• 化学式: C₆H₄N₂O₆
• 分子量: 200.108
• InChiKey: DMLFHVBDXPESMX-UHFFFAOYSA-N

物化性质

• 熔点：
  270 °C (decomp)
• 密度：
  1.900±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5,6-二氯-2,3-二氰基吡嗪 在 cadmium(II) perchlorate 作用下， 以 乙醇 、 水 为溶剂， 反应 72.0h， 以75%的产率得到5,6-二羟基吡嗪-2,3-二羧酸
  参考文献：
  名称：

  一种采用 acis 构型的新型镍 (II) 配合物：[NiL2(H2O)4] (L = 1,4-Dihydropyrazine-2,3-dione-5,6-dicarboxylate) 的溶剂热合成和晶体结构

  摘要：

  最近，使用水（溶剂）热技术合成具有有趣的光学和/或磁性的配位化合物引起了越来越多的兴趣。 [1,2] 大多数例子都集中在高维配位聚合物，以及取代氰基的水解，将酯或醛基团转化为羧酸酯基团通常被用作设计此类功能化配位聚合物的关键步骤。然而，很少有例子涉及在水（溶剂）热条件下其他取代基团的水解。在这里，我们介绍了新型镍 (II) 配合物 [NiL2(H2O)4] (1) (L 1,4-dihydropyrazine-2,3-dione-5,6-dicarboxylate) 的水（溶剂）热合成和晶体结构)，它采用了不寻常的顺式配置。有趣的是，在相同的溶剂热条件下，当用[Cd(ClO4)2]·6H2O代替[Ni(ClO4)2]·6H2O时，没有从反应中分离出镉配合物：只有水合的1,4-二氢吡嗪-2,3-形成二酮-5,6-二羧酸(2)。发现反应物 5,6-二氯吡嗪-2,3-二甲腈的氰基在加氢过程中已水

  DOI：

  10.1002/1099-0682(200207)2002:7<1595::aid-ejic1595>3.0.co;2-5

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Participation in Heterogeneous Communities*
  作者：Alberto Alesina、Eliana La Ferrara

  DOI：10.1162/003355300554935

  日期：2000.8

  This paper studies what determines group formation and the degree of participation when the population is heterogeneous, both in terms of income and race or ethnicity. We are especially interested in whether and how much the degree of heterogeneity in communities influences the amount of participation in different types of groups. Using survey data on group membership and data on U. S. localities, we find that, after controlling for many individual characteristics, participation in social activities is significantly lower in more unequal and in more racially or ethnically fragmented localities. We also find that those individuals who express views against racial mixing are less prone to participate in groups the more racially heterogeneous their community is. These results are consistent with our model of group formation.

  本文研究了当人口在收入、种族或民族方面存在异质性时，是什么因素决定了群体的形成和参与程度。我们尤其感兴趣的是，社区的异质性程度是否以及在多大程度上影响了不同类型群体的参与程度。利用有关团体成员的调查数据和美国地方的数据，我们发现，在控制了许多个人特征之后，参与社会活动的人数在更加不平等和种族或民族更加分散的地方明显较少。我们还发现，那些表达反对种族混合观点的个人，在其社区种族异质性越强的地方，越不愿意参加团体活动。这些结果与我们的群体形成模型是一致的。
• US4264710A
  申请人：——

  公开号：US4264710A

  公开（公告）日：1981-04-28