Norophthalminsaeure | 16305-88-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Norophthalminsaeure
• 英文别名: Norophthalmsaeure；γ-glutamyl=>alanyl=>-glycine；γ-Glutamyl=>alanyl=>-glycin；2-amino-5-[[1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 16305-88-7
• 化学式: C₁₀H₁₇N₃O₆
• 分子量: 275.261
• InChiKey: RPVCUZZJCXVVDW-UHFFFAOYSA-N

物化性质

• 熔点：
  195-199 °C (decomp)
• 沸点：
  722.5±60.0 °C(Predicted)
• 密度：
  1.382±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  159
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Furanone derivatives
  申请人：——

  公开号：US20030176361A1

  公开（公告）日：2003-09-18

  Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

  呋喃酮衍生物及其药用盐具有细胞保护活性和对神经炎症以及神经退行性疾病的保护活性；它们在中风、脑缺血、心肌梗死、心肌缺血、慢性心力衰竭、炎症和其他氧化应激相关疾病的治疗中具有用途，同时也适用于阿尔茨海默病和老年性痴呆症的治疗；它们还可用于制造用于治疗这些疾病的药物配方。
• ALKYLAMINE-SUBSTITUTED PERTHIOCARBAMATES AS DUAL PRECURSORS TO HYDROPERSULFIDE AND CARBONYL SULFIDE
  申请人：The Johns Hopkins University

  公开号：US20210238134A1

  公开（公告）日：2021-08-05

  Alkylamine-substituted perthiocarbamates capable of controllable release of hydropersulfides (RSSH) and carbonyl sulfide (COS) and their use in treating or preventing ischemia-reperfusion injury are described.

  描述了能够控制释放过硫酸氢（RSSH）和羰基硫化物（COS）的烷基胺取代过硫氨酸盐，以及它们在治疗或预防缺血再灌注损伤中的应用。
• STABILIZING COMPOSITION FOR IMMOBILIZED BIOMOLECULES
  申请人：LEUKOCARE AG

  公开号：EP3249405A2

  公开（公告）日：2017-11-29

  The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.

  本发明涉及一种组合物的用途，该组合物包括(a)至少三种不同的氨基酸，(b)至少两种不同的氨基酸和一种皂素或(c)至少一种二肽或三肽，用于稳定固定在固体载体上的生物大分子。本发明还涉及一种生产稳定化生物大分子的方法，包括将生物大分子包埋在根据本发明的组合物中，以及生产附有生物大分子的固体载体的方法。本发明还涉及一种可通过本发明方法生产或制造的固体载体，以及一种使用本发明载体诊断疾病的方法。
• MODIFIED ENZYME AND USE THEREOF
  申请人：Kaneka Corporation

  公开号：EP3536782A1

  公开（公告）日：2019-09-11

  The present invention provides, by modifying a wild-type glutathione synthetase, a modified glutathione synthetase which has a more stably retained activity, particularly a higher thermal stability, and/or a transformant capable of producing the modified glutathione synthetase. A polypeptide in accordance with the present invention is a polypeptide which (a) is capable of carrying out a reaction of binding glycine to γ-glutamyl dipeptide and (b) has a higher thermal stability and/or a higher storage stability as compared with glutathione synthetase consisting of an amino acid sequence of SEQ ID NO: 1 shown in the Sequence Listing.

  本发明通过修饰野生型谷胱甘肽合成酶，提供了一种具有更稳定的活性，特别是更高的热稳定性的修饰谷胱甘肽合成酶，和/或一种能够产生修饰谷胱甘肽合成酶的转化体。 根据本发明的多肽是一种多肽，它(a)能够进行甘氨酸与γ-谷氨酰二肽的结合反应，(b)与由序列表中所示的 SEQ ID NO: 1 的氨基酸序列组成的谷胱甘肽合成酶相比，具有更高的热稳定性和/或更高的贮存稳定性。
• Method for preventing the unfolding of a (poly)peptide and/or inducing the (re-)folding of a (poly)peptide
  申请人：Leukocare AG

  公开号：US10421776B2

  公开（公告）日：2019-09-24

  The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.

  本发明涉及一种在干燥过程中防止（多）肽展开和/或在干燥后诱导（多）肽（再）折叠的方法，包括将（多）肽包埋在水溶液中的步骤，其中该溶液包括(i)至少三种不同的氨基酸，或(ii)至少一种二肽或三肽；并且其中该溶液不含或基本上不含(a)糖；和(b-i)蛋白质；和/或(b-ii)变性化合物；或 (ii) 至少一种二肽或三肽；其中溶液不含或基本上不含 (a) 糖；和 (b-i) 蛋白质；和/或 (b-ii) 变性化合物；和 (c) 硅烷。