Arphamenine B

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arphamenine B
• 英文别名: 5-amino-8-(diaminomethylideneamino)-2-[(4-hydroxyphenyl)methyl]-4-oxooctanoic acid
• 化学式: C₁₆H₂₄N₄O₄
• 分子量: 336.39
• InChiKey: RRJCLYMGCZJLBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  165
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• VERFAHREN ZUR AKTIVIERUNG REGULATORISCHER T-ZELLEN
  申请人：IMTM GmbH

  公开号：EP2178527A1

  公开（公告）日：2010-04-28
• METHOD FOR ACTIVATING REGULATORY T-CELLS
  申请人：Ansorge Siegfried

  公开号：US20110117069A1

  公开（公告）日：2011-05-19

  The invention relates to a method for activating regulatory t-cells (Treg-cells) of the human or animal body, comprising a step of bringing into contact the regulatory t-cells (Treg-cells) in a suitable liquid medium with one or a plurality of inhibitors of alanyl-amino peptidase (amino peptidase N; APN) and/or with one or a plurality of inhibitors of peptidases with the same substrate specificity to induce a suppressive effect of the regulatory t-cells (Treg-cells).
• METHODS AND COMPOSITIONS FOR REMOVING, REDUCING, DISPERSING, DISRUPTING OR ERADICATING BIOFILMS AND DETERMINING THE NUMBER OF BACTERIAL POPULATION IN BIOFILM OR A CULTURE CONTAINING BACTERIAL AGGREGATE
  申请人：INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

  公开号：US20190083619A1

  公开（公告）日：2019-03-21

  Methods for removing, reducing, dispersing, disrupting or eradicating biofilms present on a surface may include contacting the biofilm with a composition including an agent that reduces the potency of an aminopeptidase in the biofilm. The agent may reduce expression, secretion or extracellular activity of the aminopeptidase in the biofilm. The biofilm may be formed by P. aeruginosa or P. stutzeri . The composition may enhance the sensitivity of P. aeruginosa to ciprofloxacin. Methods of determining the number of bacterial population in biofilm or a culture containing bacterial aggregate may include dispersing the bacterial aggregate or biofilm by using a composition comprising exogenous PslG. The number of bacteria may be determined based on the dispersed bacteria.
• [DE] VERFAHREN ZUR AKTIVIERUNG REGULATORISCHER T-ZELLEN<br/>[EN] METHOD FOR ACTIVATING REGULATORY T-CELLS<br/>[FR] PROCÉDÉ D'ACTIVATION DE LYMPHOCYTES T RÉGULATEURS
  申请人：IMTM GMBH

  公开号：WO2009024348A1

  公开（公告）日：2009-02-26

  Die Erfindung betrifft ein Verfahren zur Aktivierung regulatorischer T-Zellen (Treg-Zellen) des menschlichen oder tierischen Körpers, umfassend einen Schritt des In-Kontakt-Bringens der regulatorischen T-Zellen (Treg-Zellen) in einem geeigneten flüssigen Medium mit einem oder mehreren Inhibitoren von Alanyl-Aminopeptidase (Aminopeptidase N; APN) und/oder mit einem oder mehreren Inhibitoren von Peptidasen gleicher Substratspezifität unter Induktion einer suppressiven Wirkung der regulatorischen T-Zellen (Treg-Zellen).