(2R)-2-amino-3-[2-(aminomethyl)phenyl]propanoic Acid | 1217601-79-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-amino-3-[2-(aminomethyl)phenyl]propanoic Acid
• CAS: 1217601-79-0
• 化学式: C₁₀H₁₄N₂O₂
• 分子量: 194.23
• InChiKey: RDAKEAJYLGZEEA-SECBINFHSA-N

物化性质

• 沸点：
  370.7±37.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10457687B2

  公开（公告）日：2019-10-29

  Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.

  式(I)化合物： 其中 R1、R2、R5、R6、R7、R12、X、Y、A、E 和 n 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂的病症。
• Cyclic peptides multimers targeting alpha-4-beta-7 integrin
  申请人：Zealand Pharma A/S

  公开号：US11111273B2

  公开（公告）日：2021-09-07

  There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).

  本文描述的多聚物由多个共价连接在一起的化合物组成，这些化合物分别独立地属于式 (I)。
• NEW AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3313850B1

  公开（公告）日：2018-10-03
• AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20190031675A1

  公开（公告）日：2019-01-31

  Compounds of formula (I): wherein R 1 , R 2 , R 5 , R 6 , R 7 , R 12 , X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.
• CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
  申请人：ENCYCLE THERAPEUTICS, INC.

  公开号：US20200216501A1

  公开（公告）日：2020-07-09

  There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).