16,16-Difluoro-15-hydroxy-18-methyl-9-oxo-11,15-epoxyprostan-1-oic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 16,16-Difluoro-15-hydroxy-18-methyl-9-oxo-11,15-epoxyprostan-1-oic acid
• 英文别名: 7-[2-(1,1-difluoro-3-methylpentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-yl]heptanoic acid
• 化学式: C₂₁H₃₄F₂O₅
• 分子量: 404.5
• InChiKey: SDDSJMXGJNWMJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHOD FOR THE LONG TERM NSAID USE
  申请人：Ueno Ryuji

  公开号：US20110034424A1

  公开（公告）日：2011-02-10

  Provided is a method for the long term treatment of a condition or disease which is one of the indications for NSAID use in a human patient, which comprises administering to the patient a pharmaceutically effective amount of a NSAID and at least 36 mcg per day of cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide. By administering cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide in combination with a NSAID, the patient can receive the NSAID for longer time period.