methyl (S)-3-amino-3-(2-chlorophenyl)propionate | 1228559-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (S)-3-amino-3-(2-chlorophenyl)propionate
• 英文别名: methyl (3S)-3-amino-3-(2-chlorophenyl)propanoate
• CAS: 1228559-30-5
• 化学式: C₁₀H₁₂ClNO₂
• 分子量: 213.664
• InChiKey: DCRQVNQTTSOOAI-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5,6,6-tetramethyl-2-(4-nitrophenoxy)-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide 、 methyl (S)-3-amino-3-(2-chlorophenyl)propionate 在 氨 、 Sodium sulfate-III 、 C17H23ClN2O5S 作用下， 以 二氯甲烷 、 N,N-二异丙基乙胺 为溶剂， 反应 16.0h， 以This gave the product (191 mg) with a molecular weight of 402.9 g/mol (C17H23ClN2O5S)的产率得到(S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester
  参考文献：
  名称：

  Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof

  摘要：

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。

  公开号：

  US08871758B2

文献信息

• [EN] TACHYKININ RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR TACHYKININE
  申请人：LILLY CO ELI

  公开号：WO2005000821A1

  公开（公告）日：2005-01-06

  The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.

  本发明涉及选择性NK-1受体拮抗剂的化学式(I)或其药用盐，用于治疗与过多的缓激肽相关的疾病。
• DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130345125A1

  公开（公告）日：2013-12-26

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。
• DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130338150A1

  公开（公告）日：2013-12-19

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。
• PROCESS FOR PREPARING CLOPIDOGREL
  申请人：Sajja Eswaraiah

  公开号：US20070225320A1

  公开（公告）日：2007-09-27

  A process for preparing clopidogrel or a salt thereof.

  制备氯吡格雷或其盐的方法。
• Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
  申请人：Boehme Thomas

  公开号：US08871758B2

  公开（公告）日：2014-10-28

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。