halfordin | 18646-71-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: halfordin
• 英文别名: 4,5,6-Trimethoxyfuro[3,2-g]chromen-7-one
• CAS: 18646-71-4
• 化学式: C₁₄H₁₂O₆
• 分子量: 276.246
• InChiKey: SHOQQSABOUVQLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  518.3±50.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  67.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  halfordin 在 臭氧 、 溶剂黄146 、 乙酸乙酯 作用下， 生成 7-hydroxy-3,4,5-trimethoxy-2-oxo-2H-chromene-6-carbaldehyde
  参考文献：
  名称：

  Hegarty; Lahey, Australian Journal of Chemistry, 1956, vol. 9, p. 120,130

  摘要：

  DOI：

文献信息

• [EN] BIOACTIVE COMPOUND<br/>[FR] COMPOSÉ BIOACTIF
  申请人：HARDIE HEALTH LTD

  公开号：WO2020044245A1

  公开（公告）日：2020-03-05

  The invention relates to a novel furan-containing sesquiterpene with the structure shown in Formula (X). (X) It can be obtained from the bark of the Melicope latifolia tree in relatively high concentration and has been found to have antibiotic properties.

  该发明涉及一种含有呋喃的新型倍半萜化合物，其结构如公式（X）所示。它可以从宽叶山橙树的树皮中以相对较高的浓度获得，并发现具有抗生素特性。
• Drug dispenser
  申请人：Medipen Limited

  公开号：EP0181184A2

  公开（公告）日：1986-05-14

  57 A drug dispenser comprises a reservoir in which a drug substance is contained in solution. A tip or applicator is connected outside the reservoir and is in flow communication with an absorbent transfer member, which member sits in the reservoir and can absorb the drug solution and convey it to the tip. The arrangement is such that the drug solution is only able to leave the reservoir when contact is made between the tip and a solid surface, such as the body to be treated. On such contact a steady stream of drug solution can be applied to the solid surface by movement of the tip on the surface. The drug dispenser is designed to be used as a small hand-held unit.

  57 配药器包括一个贮液器，贮液器内装有药物溶液。 一个喷头或涂抹器连接在贮液器外，并与一个吸收传送部件相通，该部件位于贮液器内，可吸收药物溶液并将其传送到喷头。 这种安排使药物溶液只有在喷头与固体表面（如待处理的身体）接触时才能离开贮液器。 在这种接触中，通过喷头在固体表面上的移动，可将稳定的药物溶液流涂抹到固体表面上。 配药器设计成手持式小型装置。
• Phototherapeutical apparatus and method for the treatment and prevention of diseases of body cavities
  申请人：——

  公开号：US20040204747A1

  公开（公告）日：2004-10-14

  A phototherapeutical apparatus and method are described. The apparatus includes an ultraviolet light source, an optical guidance system, and a patient interface. The patient interface is insertable at least partially into a body cavity and is operable to apply the guided ultraviolet light to a tissue surface of a body cavity. The method includes providing the phototherapeutical apparatus, preparing for the application of the phototherapeutical apparatus, inserting the patient interface at least partially into a body cavity, and applying the ultraviolet light by the patient interface to a tissue surface of a body cavity, wherein the tissue of the body cavity has an inflammatory or a hyperproliferative disease. The inflammatory diseases include rhinitis, sinusitis and rhinosinusitis. A photochemotherapeutical method is also described, using photosensitizing substances, such as psoralen before treatment with ultraviolet light. The phototherapeutical method is also effective for the prevention of inflammatory or hyperproliferative diseases.

  本文描述了一种光疗设备和方法。该设备包括紫外线光源、光学引导系统和患者界面。患者接口可至少部分插入体腔，并可将引导的紫外线照射到体腔的组织表面。该方法包括提供光治疗仪器，为光治疗仪器的应用做准备，将患者接口至少部分插入体腔，以及通过患者接口将紫外线照射到体腔的组织表面，其中体腔的组织患有炎症或过度增生疾病。炎症性疾病包括鼻炎、鼻窦炎和鼻窦炎。还描述了一种光化学治疗方法，在使用紫外线治疗前使用光敏物质，如补骨脂素。这种光疗方法还能有效预防炎症或过度增生性疾病。
• A MEDICATED WIPE
  申请人：BIOGLAN LABORATORIES LTD.

  公开号：EP0759746A1

  公开（公告）日：1997-03-05
• PHOTOTHERAPEUTICAL APPARATUS
  申请人：Rhinolight Ltd.

  公开号：EP1420857B1

  公开（公告）日：2009-05-06