[3,4,6-Tris(acetyloxy)-5-hydroxyoxan-2-yl]methyl acetate | 4692-12-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [3,4,6-Tris(acetyloxy)-5-hydroxyoxan-2-yl]methyl acetate
• 英文别名: (3,4,6-triacetyloxy-5-hydroxyoxan-2-yl)methyl acetate
• CAS: 4692-12-0；13036-15-2
• 化学式: C₁₄H₂₀O₁₀
• 分子量: 348.3
• InChiKey: SHBHJRVMGYVXKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  10

安全信息

• 危险性防范说明：
  P501,P270,P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313,P301+P312+P330
• 危险性描述：
  H302,H315,H319

文献信息

• Inflammation imaging and therapy
  申请人：Isis Innovation Limited

  公开号：US10016518B2

  公开（公告）日：2018-07-10

  An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or its mimetics. Lewis A and Lewis B and its mimetics are also provided for use in the therapeutic treatment of inflammatory diseases, autoimmune diseases and cancer.

  一种成像剂，包含寡糖分子与成像分子的共轭物。寡糖是路易斯 A 或路易斯 B 或其模拟物，或路易斯 A 或路易斯 B 或其模拟物的药学上可接受的盐或 PEG 化形式。Lewis A 和 Lewis B 及其模拟物还可用于炎症性疾病、自身免疫性疾病和癌症的治疗。
• DRUG DELIVERY
  申请人：Oxford University Innovation Limited

  公开号：US20210228725A1

  公开（公告）日：2021-07-29

  A drug delivery vehicle comprising a vesicle conjugated to one or more targeting groups, wherein the targeting groups comprise an oligosaccharide which is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of the oligosaccharide: (I) wherein R represents the point of attachment to the vesicle.10
• COMPOSITIONS AND METHODS FOR TREATING CANCER AND AUTOIMMUNE DISEASES
  申请人：CEDARS-SINAI MEDICAL CENTER

  公开号：US20210299176A1

  公开（公告）日：2021-09-30

  Described herein are compositions and methods for treating cancer and autoimmune diseases.
• US9751844B2
  申请人：——

  公开号：US9751844B2

  公开（公告）日：2017-09-05
• [EN] COMPOSITIONS AND METHODS FOR TREATING CANCER AND AUTOIMMUNE DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER ET DE MALADIES AUTO-IMMUNES
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2020033715A1

  公开（公告）日：2020-02-13

  Described herein are compositions and methods for treating cancer and autoimmune diseases.