3,4,5-tris-benzoyloxy-2-benzoyloximethyl-tetrahydro-pyran | 911237-23-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,4,5-tris-benzoyloxy-2-benzoyloximethyl-tetrahydro-pyran
• 英文别名: 3,4,5-Tris-benzoyloxy-2-benzoyloxymethyl-tetrahydro-pyran；1,5-Anhydro-2,3,4,6-tetra-O-benzoyl-d-altritol；(3,4,5-tribenzoyloxyoxan-2-yl)methyl benzoate
• CAS: 911237-23-5
• 化学式: C₃₄H₂₈O₉
• 分子量: 580.591
• InChiKey: SLUHAFOOXFMQRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  苯甲酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,4,5-tris-benzoyloxy-2-benzoyloximethyl-tetrahydro-pyran
  参考文献：
  名称：

  Asahina, Archiv der Pharmazie, 1909, vol. 247, p. 158

  摘要：

  DOI：

文献信息

• Glucose conjugates of triptolide, analogs and uses thereof
  申请人：The Johns Hopkins University

  公开号：US10695319B2

  公开（公告）日：2020-06-30

  Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

  本研究提供了通过三苯内酯与葡萄糖共轭形成葡萄糖-三苯内酯共轭物而生成的化合物，与天然存在的三苯内酯化合物相比，这些化合物具有有效的抗增殖活性和更好的耐受性。
• Timosaponin compounds
  申请人：Che Chiming

  公开号：US11319338B2

  公开（公告）日：2022-05-03

  Provided herein are timosaponin compounds of Formula I, II, III, I′, II′ and III′, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are uses of said timosaponin compounds for preparing medicament for the treatment of diseases associated with beta-amyloid in hosts or subjects in need thereof.

  本文提供了式Ⅰ、Ⅱ、Ⅲ、Ⅰ′、Ⅱ′和Ⅲ′的噻吗皂苷化合物、包含这些化合物的药物组合物及其制备工艺。还提供了所述替莫索皂苷化合物用于制备治疗宿主或有需要的受试者与β-淀粉样蛋白相关疾病的药物的用途。
• GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF
  申请人：The Johns Hopkins University

  公开号：US20190038596A1

  公开（公告）日：2019-02-07

  Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
• ENDOSOMAL CLEAVABLE LINKERS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20220177885A1

  公开（公告）日：2022-06-09

  The present disclosure relates generally to cleavable linkers and uses thereof.
• Asahina, Archiv der Pharmazie, 1909, vol. 247, p. 158
  作者：Asahina

  DOI：——

  日期：——