[7-(3,3-dimethyloxirane-2-carbonyl)-1'-formyl-1',6'-dimethyl-3'a-(methylamino)-2-oxospiro[1H-indole-3,2'-4,6,7,8,9,9a,10,10a-octahydro-3H-cyclopenta[b]quinolizine]-8'-yl] butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [7-(3,3-dimethyloxirane-2-carbonyl)-1'-formyl-1',6'-dimethyl-3'a-(methylamino)-2-oxospiro[1H-indole-3,2'-4,6,7,8,9,9a,10,10a-octahydro-3H-cyclopenta[b]quinolizine]-8'-yl] butanoate
• 化学式: C₃₂H₄₃N₃O₆
• 分子量: 565.7
• InChiKey: SPWNWIUSSBUTEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Novel physiologically active substances pf127oa, b and c substances
  申请人：Kushida Nobuaki

  公开号：US20070105883A1

  公开（公告）日：2007-05-10

  This invention provides novel PF1270A substance, PF1270B substance and PF1270C substance represented by the following formula (1) or pharmaceutically acceptable salts thereof, a method for producing the same and a pharmaceutical composition which comprises at least one of the same as the active ingredient. Since a group of the PF1270 substances of the invention show high affinity for histamine H 3 receptor, they are expected as novel histamine H 3 receptor ligands useful as medicaments.
• US7501431B2
  申请人：——

  公开号：US7501431B2

  公开（公告）日：2009-03-10