Ser-His | 67726-09-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ser-His
• 英文别名: (2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
• CAS: 67726-09-4
• 化学式: C₉H₁₄N₄O₄
• 分子量: 242.23
• InChiKey: YZMPDHTZJJCGEI-BQBZGAKWSA-N

物化性质

• 沸点：
  763.4±60.0 °C(Predicted)
• 密度：
  1.492±0.06 g/cm3(Predicted)
• 溶解度：
  溶于二甲基亚砜
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  5

制备方法与用途

生物活性方面，H-Ser-His-OH 是一种具有水解裂解活性的短肽，并且它也是一种内源性代谢物。

文献信息

• Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases
  申请人：Avirid, Inc.

  公开号：US10335372B2

  公开（公告）日：2019-07-02

  Antiviral compositions comprising a modified nuclease, or a plurality of such modified nucleases having at least one non-natural amino acid residue substituted for a naturally occurring amino acid in a parent nuclease are provided, as are methods of use and kits providing unit dosages of such compositions.

  提供了抗病毒组合物，该组合物包含改性核酸酶或多个此类改性核酸酶，其至少一个非天然氨基酸残基取代了母体核酸酶中的天然氨基酸，还提供了使用方法和提供单位剂量此类组合物的试剂盒。
• COMPOSITIONS WITH MODIFIED NUCLEASES TARGETED TO VIRAL NUCLEIC ACIDS AND METHODS OF USE FOR PREVENTION AND TREATMENT OF VIRAL DISEASES
  申请人：Avirid, Inc.

  公开号：EP1734991A2

  公开（公告）日：2006-12-27
• JPS60248618A
  申请人：——

  公开号：JPS60248618A

  公开（公告）日：1985-12-09
• Components for producing amphoteric liposomes
  申请人：Essler Frank

  公开号：US20050164963A1

  公开（公告）日：2005-07-28

  The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.
• Compositions with Modified Nucleases Targeted to Viral Nucleic Acids and Methods of Use for Prevention and Treatment of Viral Diseases
  申请人：Appelbaum Jacob G.

  公开号：US20090047272A1

  公开（公告）日：2009-02-19

  Antiviral compositions comprising a modified nuclease, or a plurality of such modified nucleases having at least one non-natural amino acid residue substituted for a naturally occurring amino acid in a parent nuclease are provided, as are methods of use and kits providing unit dosages of such compositions.