(2S,5R)-5-methylpyrrolidine-2-carboxylic acid | 38228-16-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,5R)-5-methylpyrrolidine-2-carboxylic acid
• 英文别名: (5R)-5-methyl-L-proline；Rel-(2S,5R)-5-methylpyrrolidine-2-carboxylic acid
• CAS: 38228-16-9
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: YNSYWEFVEIFJPZ-UHNVWZDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2S)-5-methyl-2,3-dihydro-1H-pyrrole-2-carboxylic acid 生成 (2S,5R)-5-methylpyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  BELOKON, YURI N.;BULYCHEV, ALEKSANDR G.;PAVLOV, VIACHESLAV A.;FEDOROVA, E+, J. CHEM. SOC. PERKIN TRANS PT I,(1988) N 8, C. 2075-2083

  摘要：

  DOI：

文献信息

• Activation and Characterization of Bohemamine Biosynthetic Gene Cluster from <i>Streptomyces</i> sp. CB02009
  作者：Ling Liu、Sainan Li、Runze Sun、Xiangjing Qin、Jianhua Ju、Changsheng Zhang、Yanwen Duan、Yong Huang

  DOI：10.1021/acs.orglett.0c01224

  日期：2020.6.19

  monooxygenase BhmK are responsible for the formation of the pyrrolizidine core, which is further methylated on C-7 by methyltransferase BhmG. The 9-methyl group of BHMs is instead originated from a nonproteinogenic amino acid (2S,5S)-5-methylproline.

  Bohemamines（BHMs）是细菌生物碱，含有带有两个不同甲基的吡咯烷核核心。在这里，我们报告使用核糖体工程方法激活BHMs生物合成。所述表征BHM基因簇揭示了非核糖体肽合成酶BhmJ和拜尔-维利格单加氧酶BhmK分别负责双吡咯烷核心，它是由甲基BhmG上C-7进一步甲基化的形成。相反，BHM的9-甲基基团起源于非蛋白氨基酸（2 S，5 S）-5-甲基脯氨酸。
• Imidazothiazole derivatives
  申请人：Kawato Haruko

  公开号：US20090312310A1

  公开（公告）日：2009-12-17

  There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R 1 , R 2 , R 3 , R 4 , and R 5 in the formula (1) each has the same meaning as defined in the specification.

  提供了一种新的化合物，它抑制小鼠双分子分钟2（Mdm2）蛋白与p53蛋白之间的相互作用，并展现出抗肿瘤活性。本发明提供了一种咪唑噻唑衍生物，其表示为以下公式（1），具有各种取代基，可抑制Mdm2蛋白与p53蛋白之间的相互作用并展现出抗肿瘤活性：其中，公式（1）中的R1、R2、R3、R4和R5每个都具有规范中定义的相同含义。
• IMIDAZOTHIAZOLE DERIVATIVES
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2103619A1

  公开（公告）日：2009-09-23

  There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1, R2, R3, R4, and R5 in the formula (1) each has the same meaning as defined in the specification.

  本发明提供了一种新型化合物，它能抑制小鼠双分 2（Mdm2）蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性。本发明提供了一种由下式（1）代表的咪唑噻唑衍生物，该衍生物具有各种取代基，可抑制 Mdm2 蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性： 其中，式（1）中的 R1、R2、R3、R4 和 R5 各具有与说明书中定义的相同含义。
• IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2298778A1

  公开（公告）日：2011-03-23

  There is provided a novel compound that inhibits the interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits the interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1 R2, R3, R4, R5, Ar1, and Ar2 in formula (1) each have the same meanings as defined in the specification.

  本发明提供了一种新型化合物，它能抑制小鼠双分 2（Mdm2）蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性。 本发明提供了一种由下式（1）表示的咪唑噻唑衍生物，该衍生物具有各种取代基，可抑制 Mdm2 蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性： 其中，式（1）中的 R1 R2、R3、R4、R5、Ar1 和 Ar2 各自具有与说明书中所定义的相同的含义。
• Therapeutic compounds and methods of use thereof
  申请人：GENENTECH, INC.

  公开号：US10005724B2

  公开（公告）日：2018-06-26

  The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

  本发明提供具有通式（I）的化合物；及其药学上可接受的盐；其中变量 RA、RAA、下标 n、下标 q、环 A、X2、L、下标 m、X1、R1、R2、R3、R4、R5、D 和 E 具有本文所述的含义，以及含有此类化合物的组合物和使用此类化合物及组合物的方法。