3-Hydroxy-2-aethyl-buttersaeure | 854851-58-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxy-2-aethyl-buttersaeure
• 英文别名: 2-ethyl-3-hydroxy-butyric acid；3-Methylsaeure-pentanol-(2)；β-Oxy-pentan-γ-carbonsaeure；2-Aethyl-3-hydroxy-buttersaeure；2-Ethyl-3-hydroxybutanoic acid
• CAS: 854851-58-4
• 化学式: C₆H₁₂O₃
• mdl: MFCD16749637
• 分子量: 132.159
• InChiKey: TYBSGNFITSHAJH-UHFFFAOYSA-N

物化性质

• 沸点：
  250.5±23.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-2-aethyl-buttersaeure 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Fittig; Borstelmann; Lurie, Justus Liebigs Annalen der Chemie, 1904, vol. 334, p. 112

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基乙酰乙酸乙酯 在 sodium amalgam 作用下， 生成 3-Hydroxy-2-aethyl-buttersaeure
  参考文献：
  名称：

  Fittig; Borstelmann; Lurie, Justus Liebigs Annalen der Chemie, 1904, vol. 334, p. 112

  摘要：

  DOI：

文献信息

• Methods for treating an inflammatory condition or inhibiting JNK
  申请人：——

  公开号：US20040127536A1

  公开（公告）日：2004-07-01

  This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  这项发明通常涉及吲唑衍生物，具有以下结构： 1 或药用可接受的盐，其中R 1 ，R 2 和A如本文所述定义。这类化合物在治疗对JNK抑制剂有响应的广泛疾病和障碍，如炎症性疾病或障碍中具有用途。因此，还披露了治疗这些疾病和障碍的方法，以及包含一个或多个上述化合物的药物组合物。
• Indazole compounds, compositions thereof and methods of treatment therewith
  申请人：Bhagwat S. Shripad

  公开号：US20050009876A1

  公开（公告）日：2005-01-13

  This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

  这项发明通常涉及使用吲唑化合物来治疗或预防与蛋白激酶相关的疾病，包括酪氨酸激酶，诸如增殖性疾病、炎症性疾病、异常血管生成及其相关疾病、动脉硬化、黄斑变性、糖尿病、肥胖、疼痛等。这些方法包括向有需要的患者施用有效量的吲唑化合物，以抑制、调节或控制酪氨酸激酶信号转导。本文中提供了一种新型的吲唑化合物或其药用可接受的盐。
• ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES
  申请人：Council of Scientific and Industrial Research

  公开号：US20150210665A1

  公开（公告）日：2015-07-30

  The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

  本发明公开了一种高效的有机催化过程，用于非对称合成高对映选择性的癸内酯化合物，产量高且对映体过量大于99%。此外，本发明还揭示了一种成本效益高、改进的有机催化过程，用于从非手性、便宜且易于获得的原料中非对称合成高对映选择性的癸内酯化合物。
• Indazole derivatives as JNK inhibitors and compositions and methods related thereto
  申请人：——

  公开号：US20020103229A1

  公开（公告）日：2002-08-01

  Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: 1 wherein R 1 , R 2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  本发明公开了作为JNK选择性抑制剂的化合物。本发明的化合物是吲唑衍生物，具有以下结构： 1 其中R 1 ，R 2 和A如本文所述定义。此类化合物在治疗对JNK抑制产生响应的广泛病症方面具有用途。因此，还公开了治疗此类病症的方法，以及包含一个或多个上述化合物的药物组合物。
• Methods of making intermediates from polyhydroxyalkanoates
  申请人：——

  公开号：US20030144551A1

  公开（公告）日：2003-07-31

  Methods of forming intermediates from PHAs are disclosed.

  从PHA中形成中间体的方法已被披露。