S-(2-Methylbutanoyl)-dihydrolipoamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-(2-Methylbutanoyl)-dihydrolipoamide
• 英文别名: S-(8-amino-8-oxo-3-sulfanyloctyl) 2-methylbutanethioate
• 化学式: C₁₃H₂₅NO₂S₂
• 分子量: 291.5
• InChiKey: UFNCWFSSEGPJNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  86.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHODS FOR DECOUPLING YIELD AND PRODUCTIVITY OF A NON-CATABOLIC COMPOUND PRODUCED BY A HOST CELL
  申请人：Amyris, Inc.

  公开号：EP3980551A1

  公开（公告）日：2022-04-13
• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• COMPOSITIONS AND METHODS FOR MODULATING METABOLIC REGULATORS OF T CELL PATHOGENICITY
  申请人：The Broad Institute, Inc.

  公开号：US20220142948A1

  公开（公告）日：2022-05-12

  The subject matter disclosed herein is generally directed to modulation of Th17 differentiation and pathogenicity by use of metabolic targets. The metabolic targets are the molecules of the polyamine pathway or glycolysis pathway. Modulation of the polyamine pathway can shift Th17 pathogenicity and shift the transcriptome of Th17 cells to a Treg or Th1 transcriptome. The polyamine analogue DFMO can be used to modulate an inflammatory response. Inhibitors of enzymes in the glycolysis pathway can shift Th17 pathogenicity.
• [EN] METHODS FOR DECOUPLING YIELD AND PRODUCTIVITY OF A NON-CATABOLIC COMPOUND PRODUCED BY A HOST CELL<br/>[FR] PROCÉDÉS DE DÉCOUPLAGE DE RENDEMENT ET DE PRODUCTIVITÉ D'UN COMPOSÉ NON CATABOLIQUE PRODUIT PAR UNE CELLULE HÔTE
  申请人：AMYRIS INC

  公开号：WO2020247816A1

  公开（公告）日：2020-12-10

  Provided herein are compositions and methods for uncoupling the yield and productivity of an isoprenoid compound produced in a host cell. In some embodiments, the yield and productivity are uncoupled by genetically modifying the host cell to reduce flux through the citric acid cycle (TCA). In other embodiments, the yield and productivity are uncoupled by reducing the levels of ATP in the host cell.