gamma-glutamyl-methyl-cysteine | 91738-70-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: gamma-glutamyl-methyl-cysteine
• 英文别名: γ-Glutamyl-S-methylcystein；gamma-Glutamyl-s-methylcysteine；2-amino-5-[(1-carboxy-2-methylsulfanylethyl)amino]-5-oxopentanoic acid
• CAS: 91738-70-4
• 化学式: C₉H₁₆N₂O₅S
• 分子量: 264.302
• InChiKey: UPCDLBPYWXOCOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  gamma-glutamyl-methyl-cysteine 、 盐酸 生成 L-谷氨酸
  参考文献：
  名称：

  LARSEN, PEDER OLESEN;SUNDANL, MARIA;SZHUSTORENSEN, FINN TORVEN;WIESZORKOW+, BIOCHEM. SYST. AND ECOL., 15,(1987) N 5, 575-579

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS DE COMPOSÉS SÉLÉNOORGANIQUES ET LEURS PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：ALLTECH INC

  公开号：WO2015137983A1

  公开（公告）日：2015-09-17

  The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, Se-Adenosyl-L -homocysteine, Gamma- glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

  本申请涉及包含硒化合物的组合物，例如5'-甲基硒腺苷、Se-腺苷基-L-同型半胱氨酸、γ-谷氨酰-甲硒氨基酸、式（I）的化合物、式（II）的化合物、式（III）的化合物以及它们的组合物，并且使用这些化合物来增强线粒体功能或治疗线粒体功能障碍的方法。
• Compositions for use in golf balls
  申请人：Bulpett A. David

  公开号：US20050245652A1

  公开（公告）日：2005-11-03

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  高尔夫球由内核、外覆盖层和可选的中间层组成，外覆盖层可以包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强物理特性和/或性能特征（例如反弹系数）的组合物。最好，内核的反弹系数为0.8或更高。
• TREATMENT OF CANCER
  申请人：MOORE Jerome

  公开号：US20120238601A1

  公开（公告）日：2012-09-20

  The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

  本发明提供了用于治疗癌症的物质组合物、试剂盒和使用它们的方法。特别地，本发明提供了通过抑制聚腺苷酸核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供这些组合物的配方和给药方式。
• ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF
  申请人：Scicinski Jan

  公开号：US20140349988A1

  公开（公告）日：2014-11-27

  The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.

  本发明提供了有机硝基硫醚化合物，含有这种化合物的组合物，分离的有机硝基硫醚化合物以及使用这种化合物和组合物治疗患者的方法。本文描述的示例有机硝基硫醚化合物包括2-（3,3-二硝基氮杂环丙烷-1-基）-2-氧乙基硫醚及其变体。本发明的另一个方面提供了一种制药组合物，包括一种药学上可接受的载体和本文所述的有机硝基硫醚化合物，例如式I或II的化合物。本发明的另一个方面提供了一种治疗患者癌症的方法。该方法包括向需要治疗癌症的患者施用本文所述的有机硝基硫醚化合物的治疗有效量，例如式I或II的化合物，以治疗癌症。
• COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Alltech, Inc.

  公开号：US20160045533A1

  公开（公告）日：2016-02-18

  The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject.

  本申请涉及包含硒化合物的组合物，如5'-甲基硒腺苷、Se-腺苷基-L-同型半胱氨酸、γ-谷氨酰甲基硒蛋氨酸、式（I）、式（II）或式（III）的化合物以及它们的组合物，以及使用它们来调节受试者的葡萄糖代谢的方法。