S-(2,3-dihydroxypropyl) icosa-5,8,11,14-tetraenethioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-(2,3-dihydroxypropyl) icosa-5,8,11,14-tetraenethioate
• 化学式: C₂₃H₃₈O₃S
• 分子量: 394.6
• InChiKey: UUOPRYPOAXYNLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel E,E-diene compounds and their use as medicaments and cosmetics
  申请人：Dr. August Wolff GmbH & Co. KG Arzneimittel

  公开号：EP2666766A1

  公开（公告）日：2013-11-27

  The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的E，E-二烯化合物及其用作药物的用途，优选作为皮肤科药剂和化妆品。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏或过敏症状方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或粘膜，包括该化合物和药学和/或化妆品可接受的载体。
• [EN] NOVEL E,E-DIENE COMPOUNDS AND THEIR USE AS MEDICAMENTS AND COSMETICS<br/>[FR] NOUVEAUX COMPOSÉS E,E-DIÉNIQUES ET LEUR UTILISATION COMME MÉDICAMENTS ET PRODUITS COSMÉTIQUES
  申请人：WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR

  公开号：WO2012069605A1

  公开（公告）日：2012-05-31

  The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的E,E-二烯化合物及其作为药物的用途，优选作为皮肤科药剂和化妆品。这些新型化合物在治疗和/或预防病人的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏或过敏性疾病方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或粘膜，该组合物包括该化合物和药学和/或化妆学上可接受的载体。
• [EN] ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY<br/>[FR] ANTAGONISTES ABHD6 FAVORISANT LE BRUNISSEMENT DES TISSUS ADIPEUX BLANCS ET FONCTIONNALITÉ DES TISSUS ADIPEUX BRUNS
  申请人：VAL CHUM LTD PARTNERSHIP

  公开号：WO2015127559A1

  公开（公告）日：2015-09-03

  The present disclosure relates to compounds of formula I : compositions containing same and methods for treating or preventing a condition associated with brown adipose tissue dysfunction in a subject and/or for converting white adipose tissue into beige/brite adipose tissue.

  本公开涉及式I的化合物：包含相同化合物的组合物，以及用于治疗或预防与棕色脂肪组织功能障碍有关的疾病状态的方法，以及将白色脂肪组织转化为褐色/亮褐色脂肪组织的方法。
• NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS
  申请人：DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL

  公开号：US20150111935A1

  公开（公告）日：2015-04-23

  The present invention relates to a novel class of 1,3-benzoxazol-2(3H)-ones and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的1,3-苯并噁唑-2(3H)-酮类化合物及其作为药物的用途，尤其是作为皮肤科药剂和化妆品的用途。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏症状方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或黏膜，包括该化合物和一种药学和/或化妆学可接受的载体。
• STABLE EMULSION CONTAINING AN ACTIVE PHARMACEUTICAL INGREDIENT BASED ON N(3-METHYL-2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-5-YL)DODECANAMIDE, PRODUCTION AND USE
  申请人：Dr. August Wolff GmbH & Co. KG Arzneimittel

  公开号：EP3932395A1

  公开（公告）日：2022-01-05

  The present invention relates to an oil-in-water emulsion containing N-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)dodecanamide or a derivative, solvate, hydrate, or prodrug thereof or a pharmaceutically acceptable salt thereof, and a specific emulsifier system. Furthermore, the present invention relates to such an emulsion for use as medicament, in particular for use in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema, pro-allergic or allergic conditions in a patient. Usually, the medicament is a dermatological formulation which is topically applied to the skin or mucosa of a mammal. The present invention also relates to the non-therapeutic (cosmetic) use of the oil-in-water emulsion for treating cosmetic skin conditions and to a method for producing the oil-in-water emulsion.

  本发明涉及一种水包油型乳剂，含有 N-(3-甲基-2-氧代-2,3-二氢苯并[d]恶唑-5-基)十二酰胺或其衍生物、溶液剂、水合物或原药或其药学上可接受的盐，以及特定的乳化剂体系。此外，本发明还涉及用作药物的乳剂，特别是用于治疗和/或预防患者的炎症、刺激、瘙痒、疼痛、水肿、过敏或过敏性疾病。通常，这种药物是一种皮肤病制剂，可局部用于哺乳动物的皮肤或粘膜。本发明还涉及水包油乳剂用于治疗皮肤美容病症的非治疗（美容）用途，以及生产水包油乳剂的方法。