condilide | 24957-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: condilide
• 英文别名: Cnidilide；3-Butyl-1,3,3a,4,5,7a-hexahydro-isobenzofuran-1-on (Knidilid)；Cnidilid；3-butyl-3a,4,5,7a-tetrahydro-3H-isobenzofuran-1-one；3-butyl-3a,4,5,7a-tetrahydro-3H-2-benzofuran-1-one
• CAS: 24957-09-3
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: UXDIXFDKSPCUIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• APPLICATION OF PHTHALIDE COMPOUND
  申请人：Hawking Biological Technology Co., Ltd.

  公开号：EP2974723A1

  公开（公告）日：2016-01-20

  An application of a phthalide compound in preparing a medicament. The medicament is specially used for promoting a stem cell to secrete one of the following items: telomerase, a neurotrophic factor (brain-derived neurotrophic factor, BDNF), a stem cell chemotactic factor (stromal cell-derived factor-1, SDF1), a stem cell chemotactic factor receptor (CXC chemokine receptor 4, CXCR4), and an immunoregulatory factor; a kit comprising a phthalide compound and a stem cell is also provided.

  一种酞化合物在制备药物中的应用。该药物专门用于促进干细胞分泌以下物质之一：端粒酶、神经营养因子（脑源性神经营养因子，BDNF）、干细胞趋化因子（基质细胞衍生因子-1，SDF1）、干细胞趋化因子受体（CXC趋化因子受体4，CXCR4）和免疫调节因子；还提供了一种由邻苯二甲酸酯类化合物和干细胞组成的试剂盒。
• Method for providing an increased expression of telomerase, brain-derived neurotrophic factor, stromal cell-derived factor-1, CXC chemokine receptor 4, and/or immune regulatory factor of stem cell
  申请人：HAWKING BIOLOGICAL TECHNOLOGY CO., LTD

  公开号：US11013716B2

  公开（公告）日：2021-05-25

  A method for providing an increased expression of at least one of telomerase, brain-derived neurotrophic factor (BDNF), stromal cell-derived factor-1 (SDF1), CXC chemokine receptor 4 (CXCR4), and an immune regulatory factor of a stem cell in a subject is provided. The method comprises simultaneously or separately administering to the subject an effective amount of (a) a phthalide and (b) a stem cell.

  本发明提供了一种增加受试者体内端粒酶、脑源性神经营养因子（BDNF）、基质细胞源性因子-1（SDF1）、CXC趋化因子受体4（CXCR4）和干细胞免疫调节因子中至少一种表达的方法。该方法包括同时或分别向受试者施用有效量的(a)邻苯二甲酸盐和(b)干细胞。
• APPLICATION OF PHTHALIDE COMPOUNDS
  申请人：Hawking Biological Technology Co., Ltd.

  公开号：EP2974723B1

  公开（公告）日：2018-04-11
• US20140271568A1
  申请人：——

  公开号：US20140271568A1

  公开（公告）日：2014-09-18
• METHOD FOR PROVIDING AN INCREASED EXPRESSION OF TELOMERASE, BRAIN-DERIVED NEUROTROPHIC FACTOR, STROMAL CELL-DERIVED FACTOR-1, CXC CHEMOKINE RECEPTOR 4, AND/OR IMMUNE REGULATORY FACTOR OF STEM CELL
  申请人：HAWKING BIOLOGICAL TECHNOLOGY CO., LTD

  公开号：US20160324826A1

  公开（公告）日：2016-11-10

  A method for providing an increased expression of at least one of telomerase, brain-derived neurotrophic factor (BDNF), stromal cell-derived factor-1 (SDF1), CXC chemokine receptor 4 (CXCR4), and an immune regulatory factor of a stem cell in a subject is provided. The method comprises simultaneously or separately administering to the subject an effective amount of (a) a phthalide and (b) a stem cell.