methyl 14-hydroxytetradecanoate | 50515-98-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 14-hydroxytetradecanoate
• 英文别名: 14-hydroxytetradecanoic acid methyl ester
• CAS: 50515-98-5
• 化学式: C₁₅H₃₀O₃
• 分子量: 258.401
• InChiKey: VBKONVSYRQSMHY-UHFFFAOYSA-N

物化性质

• 熔点：
  45.5-46 °C
• 沸点：
  343.9±15.0 °C(Predicted)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 14-hydroxytetradecanoate 生成 14-羟基豆蔻酸
  参考文献：
  名称：

  Tulloch,A.P.; Spencer,J.F.T., Canadian Journal of Chemistry, 1968, vol. 46, p. 1523 - 1528

  摘要：

  DOI：
• 作为产物：
  描述：

  十四烷 生成 methyl 14-hydroxytetradecanoate
  参考文献：
  名称：

  Tulloch,A.P.; Spencer,J.F.T., Canadian Journal of Chemistry, 1968, vol. 46, p. 1523 - 1528

  摘要：

  DOI：

文献信息

• SELECTIVE PYY COMPOUNDS AND USES THEREOF
  申请人：NOVO NORDISK A/S

  公开号：US20160289283A1

  公开（公告）日：2016-10-06

  The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and derivatives thereof with a modifying group attached to the position corresponding to position 7 of hPYY(1-36). The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

  该发明涉及PYY化合物，其氨基酸在与hPYY(1-36)中位置30对应的位置被色氨酸及其衍生物取代，并且在与hPYY(1-36)中位置7对应的位置附着有修饰基团。该发明的化合物是选择性Y2受体激动剂。该发明还涉及含有这种PYY化合物和药用可接受的辅料的药物组合物，以及PYY化合物的医药用途。
• Epicuticular wax of Juniperus scopulorum
  作者：Alexander P. Tulloch、Lothar Bergter

  DOI：10.1016/0031-9422(81)85274-0

  日期：1981.1

  Abstract Epicuticular wax from Juniperus scopulorum contains hydrocarbons (16%), esters (11%), free acids (1%), nonacosan-10-ol (27%), nonacosane-diols (7%) and estolides (16%). The major hydrocarbon is tritriacontane; the principal esters are C 34 –C 46 , mainly octyl and decyl esters of C 28 -C 36 acids; and the diols consist of nonacosane-4,10-diol (57%),5,10-diol (28%), 7,10-diol (11%) and 10,13-diol

  摘要杜松的表皮蜡含有烃 (16%)、酯 (11%)、游离酸 (1%)、nonacosan-10-ol (27%)、nonacosane-diols (7%) 和 estolides (16%)。主要的碳氢化合物是三十三烷；主要酯是C 34 -C 46 ，主要是C 28 -C 36 酸的辛酯和癸酯；二醇由壬二烷-4,10-二醇（57%）、5,10-二醇（28%）、7,10-二醇（11%）和10,13-二醇（4%）组成。estolides 的水解得到酸、ω-羟基酸、α、ω-二醇、醇和羟基酸的混合物。羟基酸是一类新的 C 28 -C 36 酸，其 OH 连接到末端甲基末端的第 18 个或第 20 个碳上；主要成分是13-羟基三十二酸。描述了这种酸和 nonacosane-4,10-dione 和 nonacosane-4,10-diol 的合成。
• Lipase catalyzed synthesis of macrocyclic lactones in organic solvents
  作者：Atushi Makita、Takuya Nihira、Yasuhiro Yamada

  DOI：10.1016/s0040-4039(01)80995-3

  日期：1987.1

  A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described. The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents. This procedure is also applicable to the synthesis of asymmetric lactones.

  描述了一种从ω-羟酸甲酯制备大环内酯的新方法。该方法利用在有机溶剂中由脂肪酶催化的分子内酯交换反应。该程序也适用于不对称内酯的合成。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Selective PYY compounds and uses thereof
  申请人：Novo Nordisk A/S

  公开号：US09085637B2

  公开（公告）日：2015-07-21

  The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and derivatives thereof with a modifying group attached to the position corresponding to position 7 of hPYY(1-36). The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

  本发明涉及一种PYY化合物，其氨基酸在与hPYY（1-36）的位置30相对应的位置被色氨酸及其衍生物取代，并且在与hPYY（1-36）的位置7相对应的位置附着有修饰基团。本发明的化合物是选择性Y2受体激动剂。本发明还涉及包括这种PYY化合物和药用可接受的辅料的药物组合物，以及PYY化合物的医学用途。