2-{[5-(2-Phosphonophenoxy)pentyl]oxy}phenylphosphonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-{[5-(2-Phosphonophenoxy)pentyl]oxy}phenylphosphonic acid
• 英文别名: [2-[5-(2-phosphonophenoxy)pentoxy]phenyl]phosphonic acid
• 化学式: C₁₇H₂₂O₈P₂
• 分子量: 416.3
• InChiKey: VBINFZXCKFAQDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION
  申请人：MILLAN JOSE LUIS

  公开号：US20090156560A1

  公开（公告）日：2009-06-18

  Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.
• US8119693B2
  申请人：——

  公开号：US8119693B2

  公开（公告）日：2012-02-21
• [EN] TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION<br/>[FR] INHIBITEURS DE LA PHOSPHATASE ALCALINE NON SPÉCIFIQUES À UN TISSU ET LEURS UTILISATIONS POUR TRAITER UNE CALCIFICATION VASCULAIRE
  申请人：BURNHAM INST MEDICAL RESEARCH

  公开号：WO2009017863A2

  公开（公告）日：2009-02-05

  Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.