羟基二十二烷酸槐糖甙 | 20246-59-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 羟基二十二烷酸槐糖甙
• 英文名称: Hydroxydocosanoic acid sophoroside
• 英文别名: 13-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxydocosanoic acid
• CAS: 20246-59-7
• 化学式: C₃₈H₆₈O₁₅
• 分子量: 764.9
• InChiKey: LGIFCELMJBBHMO-SGQFWHNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  53
• 可旋转键数：
  30
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  228
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• LOW-TOXICITY SOPHOROLIPID-CONTAINING COMPOSITION AND USE THEREFOR
  申请人：Saraya Co., Ltd.

  公开号：EP3042940A1

  公开（公告）日：2016-07-13

  The present invention provides a low-toxicity sophorolipid-containing composition. The low-toxicity sophorolipid-containing composition contains at least a coloring component, an acidic SL, a fatty acid, and a hydroxy fatty acid that are derived from an SL-producing yeast culture. The composition contains the following components in the following proportions, in terms of dry weight, based on the total amount of the acidic SL, a lactonic SL, the fatty acid, and the hydroxy fatty acid in the composition taken as 100 mass%: (1) acidic SL: 94 to 99.99 mass%, (2) lactonic SL: 0 to 2 mass%, (3) total amount of fatty acid and hydroxy fatty acid: 0.01 to 4 mass%.

  本发明提供了一种含低毒性槐脂的组合物。该低毒性槐脂组合物至少含有一种着色成分、一种酸性槐脂、一种脂肪酸和一种羟基脂肪酸，这些成分均来自一种生产槐脂的酵母培养物。根据酸性 SL、乳酸 SL、脂肪酸和羟基脂肪酸在组合物中的总量（以干重计）为 100 质量%，组合物按以下比例含有以下成分： (1) 酸性 SL：94 至 99.99 质量%、 (2) 乳酸溶胶：0 至 2 质量%、 (3) 脂肪酸和羟基脂肪酸的总量：0.01 至 4 质量%。
• COMPOSITION CONTAINING SOPHOROLIPID, PHYSIOLOGICALLY ACTIVE SUBSTANCE AND OIL AND FAT, AND METHOD OF PRODUCING SAID COMPOSITION
  申请人：Saraya Co., Ltd.

  公开号：EP3117838A1

  公开（公告）日：2017-01-18

  The present invention provides an orally administered composition comprising a sophorolipid, a physiologically active substance, and an oil or fat, wherein the physiologically active substance exhibits an improved bioavailability.

  本发明提供了一种口服组合物，该组合物由槐脂、生理活性物质和油脂组成，其中生理活性物质的生物利用度有所提高。
• High-purity acid-form sophorolipid (SL) containing composition and process for preparing same
  申请人：Saraya Co., Ltd.

  公开号：US10065982B2

  公开（公告）日：2018-09-04

  The present invention provides a high-purity acid-form sophorolipid (SL)-containing composition characterized by substantially not containing acetic acid. The high-purity acid-form SL-containing composition can be produced, for example, by the following method: (i) adjusting the pH of a partially purified acid-form SL-containing composition to an acidic range; and (ii-a) subjecting an acidified partially purified acid-form SL-containing composition obtained in step (i) to chromatography to acquire a fraction containing an acid-form SL, or (ii-b) leaving the acidified partially purified acid-form SL-containing composition obtained in step (i) to stand under a low-temperature condition to acquire a resulting gelled object.

  本发明提供了一种高纯度酸式槐脂（SL）组合物，其特点是基本上不含乙酸。这种高纯度酸式槐脂组合物可通过以下方法生产： (i) 将部分纯化的含酸形式 SL 组合物的 pH 值调至酸性范围；以及 (iii-a) 将步骤(i)中获得的酸化的部分纯化的含酸型 SL 组合物进行层析，以获得含酸型 SL 的馏分，或 (ii-b) 将步骤(i)中得到的酸化的部分纯化的含酸形式 SL 的组合物在低温条件下静置，以得到胶凝物。
• Composition comprising sophorolipid, physiologically active substance and oil or fat, and method for producing the same
  申请人：SARAYA CO., LTD.

  公开号：US10307466B2

  公开（公告）日：2019-06-04

  The present invention provides an orally administered composition comprising a sophorolipid, a physiologically active substance, and an oil or fat, wherein the physiologically active substance exhibits an improved bioavailability.

  本发明提供了一种口服组合物，该组合物由槐脂、生理活性物质和油脂组成，其中生理活性物质的生物利用度有所提高。
• Low-toxicity sophorolipid-containing composition and use therefor
  申请人：Saraya Co., Ltd.

  公开号：US10688031B2

  公开（公告）日：2020-06-23

  The present invention provides a low-toxicity sophorolipid-containing composition. The low-toxicity sophorolipid-containing composition contains at least a coloring component, an acidic sophorolipid, a fatty acid, and a hydroxy fatty acid that are derived from an SL-producing yeast culture. The composition contains the following components in the following proportions, in terms of dry weight, based on the total amount of the acidic sophorolipid, a lactonic sophorolipid, the fatty acid, and the hydroxy fatty acid in the composition taken as 100 mass %: (1) acidic sophorolipid: 94 to 99.99 mass %, (2) lactonic sophorolipid: 0 to 2 mass %, (3) total amount of fatty acid and hydroxy fatty acid: 0.01 to 4 mass %.

  本发明提供了一种含低毒性槐脂的组合物。这种含低毒性槐脂的组合物至少含有一种着色成分、一种酸性槐脂、一种脂肪酸和一种羟基脂肪酸，它们都是从产生 SL 的酵母培养物中提取的。根据酸性槐脂、乳酸槐脂、脂肪酸和羟基脂肪酸在组合物中的总量（以干重计）为 100 质量百分比，组合物中含有以下比例的成分： (1) 酸性槐脂：94-99.99 质量%、 (2) 乳酸槐脂：0 至 2 质量百分数、 (3) 脂肪酸和羟基脂肪酸的总量：0.01 至 4 质量%。