N'-[(E)-(4-fluorophenyl)methylidene]-2-pyrazinecarbohydrazide | 1206198-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N'-[(E)-(4-fluorophenyl)methylidene]-2-pyrazinecarbohydrazide
• 英文别名: N'-{(1E)-[4-fluorophenyl]methylidene}pyrazine-2-carbohydrazide；LASSBio-1270；N-[(E)-(4-fluorophenyl)methylideneamino]pyrazine-2-carboxamide
• CAS: 1206198-47-1
• 化学式: C₁₂H₉FN₄O
• 分子量: 244.228
• InChiKey: BGWQSNBVMOOUBO-FRKPEAEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡嗪-2-甲酰肼 、 对氟苯甲醛 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以96%的产率得到N'-[(E)-(4-fluorophenyl)methylidene]-2-pyrazinecarbohydrazide
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates

  摘要：

  In this paper, we report the synthesis and pharmacological evaluation of pyrazine N-acylhydrazone (NAH) derivatives (2a-s) designed as novel analgesic and anti-inflammatory drug candidates. This series was planned by molecular simplification of prototype 1 (LASSBio-1018), previously described as a nonselective cyclooxygenase inhibitor. Derivatives 2a-s were evaluated in several animal models of pain and inflammation, standing-out compound 2o (2-N'-[(E)-(3,4,5-trimethoxyphenyl) methylidene]-2-pyrazinecarbohydrazide; LASSBio-1181), that was also active in a murine model of chronic inflammation (i.e., adjuvant-induced arthritis test in rats) and can be considered a new analgesic and anti-inflammatory lead for drug development. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.06.002

文献信息

• Synthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives
  作者：Fátima M.F. Vergara、Camilo H. da S. Lima、Maria das Graças M. de O. Henriques、André L.P. Candéa、Maria C.S. Lourenço、Marcelle de L. Ferreira、Carlos R. Kaiser、Marcus V.N. de Souza

  DOI：10.1016/j.ejmech.2009.08.009

  日期：2009.12

  The present article describes a series of twenty-six N'-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide (4-29), which were synthesized and evaluated for their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). Afterwards, the non-cytotoxic compounds (4, 6, 8, 15, 21, 23, 24, 27 and 28) were assessed against Mycobacterium tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA) and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 6, 23, 27 and 28 exhibited a significant activity (50-100 mu g/mL) when compared with first line drugs such as pyrazinamide and were not cytotoxic in their respective MIC values. (C) 2009 Elsevier Masson SAS. All rights reserved.
• Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates
  作者：Yolanda Karla Cupertino da Silva、Cristina Villarinho Augusto、Maria Letícia de Castro Barbosa、Gabriela Muniz de Albuquerque Melo、Aline Cavalcanti de Queiroz、Thays de Lima Matos Freire Dias、Walfrido Bispo Júnior、Eliezer J. Barreiro、Lídia Moreira Lima、Magna Suzana Alexandre-Moreira

  DOI：10.1016/j.bmc.2010.06.002

  日期：2010.7

  In this paper, we report the synthesis and pharmacological evaluation of pyrazine N-acylhydrazone (NAH) derivatives (2a-s) designed as novel analgesic and anti-inflammatory drug candidates. This series was planned by molecular simplification of prototype 1 (LASSBio-1018), previously described as a nonselective cyclooxygenase inhibitor. Derivatives 2a-s were evaluated in several animal models of pain and inflammation, standing-out compound 2o (2-N'-[(E)-(3,4,5-trimethoxyphenyl) methylidene]-2-pyrazinecarbohydrazide; LASSBio-1181), that was also active in a murine model of chronic inflammation (i.e., adjuvant-induced arthritis test in rats) and can be considered a new analgesic and anti-inflammatory lead for drug development. Published by Elsevier Ltd.