3-Hydroxy-4-methoxy-3-methyl-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxy-4-methoxy-3-methyl-4-oxobutanoic acid
• 化学式: C₆H₁₀O₅
• 分子量: 162.14
• InChiKey: VQNKVZAIEXAESZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BIOFUELS PRODUCTION FROM BIO-DERIVED CARBOXYLIC-ACID ESTERS
  申请人：Archer Daniels Midland Company

  公开号：US20170044086A1

  公开（公告）日：2017-02-16

  A process for producing biofuels compounds directly from carboxylic acid esters recovered from a fermentation system is described. The process involves taking a fermentation broth that has been reduced to a dry powder containing free organic acids; reacting the carboxylic acid in the powder with an alcohol solvent under a CO 2 -containing atmosphere in substantial absence of any other acid catalyst at a reaction temperature and pressure that corresponds to supercritical, critical or near critical conditions for at least one of the alcohol or CO 2 to synthesize an ester, then subjecting the ester to either hydrogenolysis or hydrogenation to form a biofuel.

  描述了一种直接从从发酵系统中回收的羧酸酯生产生物燃料化合物的过程。该过程涉及采取已经被还原为含有自由有机酸的干粉的发酵液；在含有CO2的气氛下，在几乎没有任何其他酸催化剂的条件下，以相应于至少一种醇或CO2的超临界、临界或接近临界条件的反应温度和压力中，将粉末中的羧酸与醇溶剂反应以合成酯，然后将酯经过氢解或加氢处理以形成生物燃料。
• Stereospecific hydrolysis of optically active esters
  申请人：——

  公开号：US20030032818A1

  公开（公告）日：2003-02-13

  1 A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q 1 are as defined in the description, starting from compounds of absolute configuration (S) by hydrolysis, in the presence of acids, of the corresponding esterified derivatives. The (R)-(I) products obtained with the process described herein are chiral synthons useful for the production of enanthiomerically pure drugs. The preparation of (R)-carnitine is also provided.

  本文介绍了一种新的、更高效、高度立体特异性的过程，用于制备通式为(R)-(I)，绝对构型为(R)的化合物，其中M、W、Q和Q1的基团如描述中所定义，从绝对构型为(S)的化合物出发，通过在酸的存在下水解相应的酯化衍生物。本文所描述的(R)-(I)产物是手性合成物，可用于生产对映纯药物。还提供了(R)-肉碱的制备方法。
• Biofuels production from bio-derived carboxylic-acid esters
  申请人：Archer Daniels Midland Company

  公开号：US10118886B2

  公开（公告）日：2018-11-06

  A process for producing biofuels compounds directly from carboxylic acid esters recovered from a fermentation system is described. The process involves taking a fermentation broth that has been reduced to a dry powder containing free organic acids; reacting the carboxylic acid in the powder with an alcohol solvent under a CO2-containing atmosphere in substantial absence of any other acid catalyst at a reaction temperature and pressure that corresponds to supercritical, critical or near critical conditions for at least one of the alcohol or CO2 to synthesize an ester, then subjecting the ester to either hydrogenolysis or hydrogenation to form a biofuel.

  本文介绍了一种直接利用从发酵系统中回收的羧酸酯生产生物燃料化合物的工艺。该工艺包括：将发酵液还原成含有游离有机酸的干粉；在基本上没有任何其他酸催化剂的情况下，在含二氧化碳的气氛中，使粉末中的羧酸与醇溶剂在反应温度和压力相当于醇或二氧化碳中至少一种物质的超临界、临界或接近临界条件下反应，合成酯，然后将酯进行氢解或氢化，形成生物燃料。
• Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10138479B2

  公开（公告）日：2018-11-27

  Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.

  提供了用于 GPP 靶向（例如用于治疗致癌 Kras 相关癌症）的方法和试剂盒，以及确定这些方法疗效的方法。
• Pharmaceutical compositions of dimethyl fumarate
  申请人：ARBOR PHARMACEUTICALS, LLC

  公开号：US11229621B2

  公开（公告）日：2022-01-25

  Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.

  本发明公开了富马酸二甲酯的药物组合物和剂型，其中某些杂质的含量较低。