2-deoxyglucose | 7087-86-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-deoxyglucose
• 英文别名: 2-DG；2-deoxy-d-glucose；deoxy glucose；D-Arabino-hexose, 2-deoxy-；3,4,5,6-tetrahydroxyhexanal
• CAS: 7087-86-7
• 化学式: C₆H₁₂O₅
• mdl: MFCD07809362
• 分子量: 164.158
• InChiKey: VRYALKFFQXWPIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

ADMET

代谢

2-脱氧-D-葡萄糖在小鼠睾丸和肝脏中转化为6-磷酸，这是在每天以50毫克/千克体重的剂量腹腔注射7天后的结果。

2-DEOXY-D-GLUCOSE WAS CONVERTED TO THE 6-PHOSPHATE IN MOUSE TESTIS AND LIVER AFTER IP INJECTION OF 50 MG/KG BODY WT DAILY FOR 7 DAYS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

大量腹腔注射2-脱氧葡萄糖在大鼠中引起了视网膜电图的变化，表现为α和β波的降低。这种效应被D-葡萄糖所拮抗。

2-DEOXYGLUCOSE INJECTED INTRAPERITONEALLY IN RATS IN LARGE DOSES CAUSED CHANGES IN THE ELECTRORETINOGRAM CONSISTING OF A DECR IN BOTH ALPHA- AND BETA-WAVES. THE EFFECT WAS ANTAGONIZED BY D-GLUCOSE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

葡萄糖的剂量超过其最大肾小管转运能力时，同时给药会抑制2-脱氧葡萄糖的肾小管重吸收。因此，肾小管重吸收的过程可能与葡萄糖的重吸收过程相同。

SIMULTANEOUS ADMIN OF GLUCOSE @ DOSE EXCEEDING ITS MAX TUBULAR TRANSPORT CAPACITY INHIBITED TUBULAR REABSORPTION OF 2-DEOXYGLUCOSE. THUS, THE PROCESS OF TUBULAR REABSORPTION IS PROBABLY THE SAME AS THAT FOR GLUCOSE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在无性腺功能的绵羊中，2-脱氧葡萄糖输注抑制了由雌二醇诱导的促黄体生成素（LH）的释放，但并未抑制由促黄体生成素释放激素（LH-RH）诱导的释放。

IN ANESTROUS SHEEP, 2-DEOXYGLUCOSE INFUSION INHIBITED LH RELEASE INDUCED BY ESTRADIOL BUT NOT BY LH-RH.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

2-脱氧-D-葡萄糖抑制X射线在小鼠艾利希腹水肿瘤细胞中引起的潜在致死性损伤的修复。

2-DEOXY-D-GLUCOSE INHIBITED REPAIR OF POTENTIALLY LETHAL DAMAGE INDUCED BY X-RAYS IN MOUSE EHRLICH ASCITES TUMOR CELLS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

2-脱氧葡萄糖在大剂量下通过大鼠腹腔注射，引起了视网膜电图的变化，表现为α波和β波的降低。

2-DEOXYGLUCOSE INJECTED INTRAPERITONEALLY IN RATS IN LARGE DOSES CAUSED CHANGES IN THE ELECTRORETINOGRAM CONSISTING OF A DECR IN BOTH ALPHA- AND BETA-WAVES.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当通过常规清除和停止流动技术研究狗和老鼠对2-脱氧葡萄糖的肾排泄时，发现它被肾小管重吸收，平均重吸收率为过滤负荷的68-89%，重吸收部位在近端小管。

WHEN THE RENAL EXCRETION OF 2-DEOXYGLUCOSE WAS STUDIED IN DOGS AND RATS BY CONVENTIONAL CLEARANCE AND STOP-FLOW TECHNIQUES, IT WAS REABSORBED BY THE RENAL TUBULES AT AN AVG OF 68-89% OF THE FILTERED LOADS AND THE REABSORPTION SITE WAS IN THE PROXIMAL TUBULES.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

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  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2018006063A1

  公开（公告）日：2018-01-04

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  申请人：Izumori Ken

  公开号：US20100105885A1

  公开（公告）日：2010-04-29

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• [EN] FUNCTIONALIZABLE MOLECULAR PROBE FOR X-RAY FLUORESCENCE IMAGING AND MULTIMODAL IMAGING<br/>[FR] SONDE MOLÉCULAIRE POUVANT ÊTRE FONCTIONNALISÉE POUR IMAGERIE DE FLUORESCENCE À RAYONS X ET IMAGERIE MULTIMODALE
  申请人：PARIS SCIENCES ET LETTRES - QUARTIER LATIN

  公开号：WO2017005822A1

  公开（公告）日：2017-01-12

  The present invention relates to a X-ray fluorescence molecular probe of formula I or a salt thereof, wherein X, Het 1, R1, Y1, Y2, L and R2 are as defined in the claims. The invention also relates to the use of the probes of the invention for X-ray fluorescence imaging, including in the context of multimodal imaging. The probes of the invention are useful in biological applications of X-ray fluorescence imaging, especially for imaging intracellular organelles and to label biomolecules. The probes of the invention may be functionalized or functionalizable.

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• [EN] CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD<br/>[FR] CONJUGUÉS D'UNE GLYCOPROTÉINE OU D'UN GLYCANE AVEC UNE CHARGE TOXIQUE
  申请人：GLYKOS FINLAND OY

  公开号：WO2014177771A1

  公开（公告）日：2014-11-06

  The invention relates to a glycoprotein-toxic pay- load molecule conjugate, a toxic payload molecule- glycan conjugate, and a pharmaceutical composi- tion.The invention further relates to a method for preparing the glycoprotein-toxic payload mole- cule conjugate, the method for modulating growth of a cell population and a method of treating tu- mour cells.

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• [EN] INHIBITORS OF MALARIAL AND PLASMODIUM FALCIPARUM HEXOSE TRANSPORTER AND USES THEREOF<br/>[FR] INHIBITEURS DU TRANSPORTEUR D'HEXOSE DE LA MALARIA ET DE PLASMODIUM FALCIPARUM ET LEURS UTILISATIONS
  申请人：UNIV TSINGHUA

  公开号：WO2021155748A1

  公开（公告）日：2021-08-12

  Provided are molecules capable of binding to binding pockets of Plasmodium falciparum hexose transporter (PfHT) or analogs thereof and complexes comprising the same. Also provided herein are inhibitors of PfHT, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors or the pharmaceutical compositions in the treatment of diseases associated with Plasmodium or PfHT or the killing or inhibiting the growth of Plasmodium. Provided are a set of structure coordinates of such binding pockets and method of using the set of structure coordinates to screen for and design compounds that are capable of binding to PfHT or analogs thereof.

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