Dimethyl 2,6-dimethyl-4-ketopimelate | 136384-91-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: Dimethyl 2,6-dimethyl-4-ketopimelate
• 英文别名: 4-Oxo-2,6-dimethyl-pimelinsaeure-diethylester；dimethyl 2,6-dimethyl-4-oxoheptanedioate；2,6-dimethyl-4-oxo-heptanedioic acid dimethyl ester；2,6-Dimethyl-4-oxo-heptandisaeure-dimethylester
• CAS: 136384-91-3；136384-94-6；136458-65-6；91967-00-9
• 化学式: C₁₁H₁₈O₅
• 分子量: 230.261
• InChiKey: ZJGCYSMROIVCBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲醇 、 alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 Dimethyl 2,6-dimethyl-4-ketopimelate
  参考文献：
  名称：

  Eskola, Annales Academiae Scientiarum Fennicae, Series A2: Chemica, 1945, # 18, p. 21

  摘要：

  DOI：

文献信息

• CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction
  作者：Saleem Farooq、Payare L. Sangwan、Rajeshwar R. Aleti、Praveen K. Chinthakindi、Mushtaq A. Qurishi、Surrinder Koul

  DOI：10.1016/j.tetlet.2012.04.071

  日期：2012.6

  An efficient one pot synthesis of γ-keto diesters through double Michael addition coupled with Nef reaction in the presence of CuCN catalyst and Cs2CO3 base is described. The reaction proceeds rapidly in DCM to give the products in good yields. A plausible mechanism is proposed.

  描述了在CuCN催化剂和Cs 2 CO 3碱存在下，通过双迈克尔加成和Nef反应有效地一锅合成γ-酮二酯。该反应在DCM中快速进行，以高收率得到产物。提出了一种合理的机制。
• Synthesis of 1,4-dicarbonyl compounds and 4-keto pimelates by palladium-catalyzed carbonylation of siloxycyclopropanes
  作者：Satoshi Aoki、Eiichi Nakamura

  DOI：10.1016/s0040-4020(01)86434-6

  日期：1991.1

  Palladium-catalyzed reaction of a siloxycyclopropane with an aryl triflate under carbon monoxide pressure (10-20 atm) in HMPA and that with carbon monoxide in chloroform provides new synthetic routes to 1,4-dicarbonyl compounds and 4-keto pimelates, respectively. The reaction of a siloxycyclopropane with a vinyl triflate, on the other hand, gives an acyloxycyclopropane instead.
• Eskola, Annales Academiae Scientiarum Fennicae, Series A2: Chemica, 1945, # 18, p. 21
  作者：Eskola

  DOI：——

  日期：——