[4,5-Diacetyloxy-3-chloro-6-[3,4-diacetyloxy-2,5-bis(chloromethyl)oxolan-2-yl]oxyoxan-2-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [4,5-Diacetyloxy-3-chloro-6-[3,4-diacetyloxy-2,5-bis(chloromethyl)oxolan-2-yl]oxyoxan-2-yl]methyl acetate
• 化学式: C₂₂H₂₉Cl₃O₁₃
• 分子量: 607.8
• InChiKey: WBOCSUAOZWICQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  159
• 氢给体数：
  0
• 氢受体数：
  13

文献信息

• Novel chlorination process for preparing sucralose
  申请人：Xu Shaojun

  公开号：US20080300392A1

  公开（公告）日：2008-12-04

  A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose from sucrose-6-esters are provided.

  一种制备三氯蔗糖-6-酯的方法，该酯是制备三氯蔗糖的关键中间体。该方法包括(a)制备一种异相混合物，其中第一相包括蔗糖-6-酯，第二相包括氯化试剂；(b)将蔗糖-6-酯与氯化试剂反应，制备三氯蔗糖-6-酯。此外，还提供了从蔗糖-6-酯制备三氯蔗糖的方法。
• Process for purification of sucralose
  申请人：Deshpande Balwant Pandurang

  公开号：US20070160732A1

  公开（公告）日：2007-07-12

  The present invention relates to a process for the purification of Sucralose of formula (I) which comprises acetylation of substantially impure Sucralose to its penultimate intermediate 4,1′,6′-trichloro-4,1′,6′-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) followed by purification of TOPSA and then deacetylation of purified TOPSA.
• US7741477B2
  申请人：——

  公开号：US7741477B2

  公开（公告）日：2010-06-22
• [EN] NOVEL CHLORINATION PROCESS FOR PREPARING SUCRALOSE<br/>[FR] NOUVEAU PROCÉDÉ DE CHLORATION DESTINÉ À PRÉPARER DU SUCRALOSE
  申请人：POLYMED THERAPEUTICS INC

  公开号：WO2008150379A1

  公开（公告）日：2008-12-11

  [EN] A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose are provided.
  [FR] L'invention concerne un procédé destiné à préparer un 6-ester de sucralose, un intermédiaire-clé pour la préparation de sucralose. Le procédé consiste à (a) créer un mélange hétérogène comprenant une première phase contenant un 6-ester de saccharose et une seconde phase contenant un réactif de chloration ; et (b) à faire réagir le 6-ester de saccharose avec le réactif de chloration afin de préparer un 6-ester de sucralose. En outre, l'invention concerne des procédés de préparation de sucralose.
• [EN] COST EFFICIENT PROCESS FOR PREPARATION OF SUCRALOSE<br/>[FR] PROCESSUS RENTABLE DE PREPARATION DE SUCRALOSE
  申请人：ALEMBIC LTD

  公开号：WO2010013157A2

  公开（公告）日：2010-02-04

  The present invention relates to cost efficient process for preparation of sucralose. The present invention relates to recovery of the reagents from feed mixture obtained in various steps of sucralose. Particularly, the present invention relates to recovery of trityl chloride, β-picoline, triphenylphosphine oxide (TPPO) and methyl acetate.