Saframycin precursor

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Saframycin precursor
• 英文别名: 2-amino-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoic acid
• 化学式: C₁₁H₁₅NO₄
• 分子量: 225.24
• InChiKey: WCPBEUSWIVLNSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Gene cluster involved in safracin biosynthesis and its uses for genetic engineering
  申请人：Velasco Iglesias Ana

  公开号：US20060134764A1

  公开（公告）日：2006-06-22

  A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.

  基因簇具有开放阅读框，可编码足以指导合成黄霉素分子的多肽。
• THE GENE CLUSTER INVOLVED IN SAFRACIN BIOSYNTHESIS AND ITS USES FOR GENETIC ENGINEERING
  申请人：PHARMA MAR, S.A.

  公开号：EP1576159A1

  公开（公告）日：2005-09-21
• The Gene Cluster Involved in Safracin Biosynthesis and Its Uses for Genetic Engineering
  申请人：Velasco Iglesias Ana

  公开号：US20080182302A2

  公开（公告）日：2008-07-31

  A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.
• Biosynthetic Pathway for Heterologous Expression of a Nonribosomal Peptide Synthetase Drug and Analogs
  申请人：Sherman David H.

  公开号：US20130095533A1

  公开（公告）日：2013-04-18

  The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
• BIOSYNTHETIC PATHWAY FOR HETEROLOGOUS EXPRESSION OF A NONRIBOSOMAL PEPTIDE SYNTHETASE DRUG AND ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150050704A1

  公开（公告）日：2015-02-19

  The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.