komaroine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: komaroine
• 英文别名: Komaroin；1-(3-propylphenyl)-9H-pyrido[3,4-b]indole
• 化学式: C₂₀H₁₈N₂
• 分子量: 286.376
• InChiKey: WISHAHVIQZDSHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  9H-吡啶并[3,4-b]吲哚-1-醇 在 四(三苯基膦)钯 、 sodium carbonate 、 N,N-二甲基苯胺 、 三氯氧磷 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 53.0h， 生成 komaroine
  参考文献：
  名称：

  Bracher, Franz; Hildebrand, Dirk, Liebigs Annalen der Chemie, 1992, # 12, p. 1315 - 1320

  摘要：

  DOI：

文献信息

• Alkaloids of Nitraria komarovii. XI. Structure of komavicine and the products of the dehydrogenation of the nitrarine method of dehydrogenation in the quinolinyl-?-carboline series
  作者：T. S. Tulyaganov

  DOI：10.1007/bf00631008

  日期：——

  The new alkaloid komavicine has been isolated from the epigeal part ofNitraria komarovii, and its structure has been established on the basis of spectral characteristics and chemical transformations. The products of the dehydrogenation of nitrarine with selenium and sulfur have been studied. A method has been developed for the dehydrogenation of dihydro and tetrahydro derivatives in the quinolinyl-β-carboline

  新生物碱komavicine是从Nitraria komarovii的表生部分分离出来的，其结构是在光谱特征和化学转化的基础上确定的。研究了硝基氮与硒和硫的脱氢产物。已经开发了一种用于喹啉基-β-咔啉系列中的二氢和四氢衍生物脱氢的方法。
• Alkaloids ofNitraria komarovii. IX. Structure of komaroine
  作者：T. S. Tulyaganov、A. A. Ibragimov、S. Yu. Yunusov

  DOI：10.1007/bf00575785

  日期：——
• Anti-Inflammatory and Anti-Allergy Extracts from Nettle
  申请人：Alberte Randall S.

  公开号：US20100009927A1

  公开（公告）日：2010-01-14

  The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.
• Extracts of Curcuma and Methods of Use Thereof
  申请人：Alberte Randall S.

  公开号：US20100098788A1

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• [EN] ANTI-INFLAMMATORY AND ANTI-ALLERGY EXTRACTS FROM NETTLE<br/>[FR] EXTRAITS D'ORTIE ANTI-INFLAMMATOIRES ET ANTIALLERGIQUES
  申请人：HERBALSCIENCE GROUP LLC

  公开号：WO2010009091A2

  公开（公告）日：2010-01-21

  The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.

表征谱图