3-Hydroxyisobutyryl-CoA | 319440-43-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxyisobutyryl-CoA
• 英文别名: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxy-2-methylpropanethioate
• CAS: 319440-43-2
• 化学式: C₂₅H₄₂N₇O₁₈P₃S
• 分子量: 853.6
• InChiKey: WWEOGFZEFHPUAM-UHFFFAOYSA-N

物化性质

• 密度：
  1.87±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  54
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  409
• 氢给体数：
  10
• 氢受体数：
  23

文献信息

• Method for producing methacrylyl-CoA
  申请人：Mitsubishi Chemical Corporation

  公开号：US10323264B2

  公开（公告）日：2019-06-18

  The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus Pseudomonas or Rhodococcus.

  本发明提供了一种生产甲基丙烯酰-CoA 的方法，该方法利用一种具有脱水酶活性的酶将 3-羟基异丁酰-CoA 转化为甲基丙烯酰-CoA，作为一种利用酶催化剂生产甲基丙烯酰-CoA 的方法。在这种生产方法中，具有脱水酶活性的酶将 3-羟基异丁酰-CoA 转化为甲基丙烯酰-CoA 的转化率为 50%或更高。此外，在这种生产方法中，具有脱水酶活性的酶来源于假单胞菌属或红球菌属的微生物。
• METHOD FOR PRODUCING METHACRYLYL-COA
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：US20160145665A1

  公开（公告）日：2016-05-26

  The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus Pseudomonas or Rhodococcus.
• Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same
  申请人：GeneSys Consulting, LLC

  公开号：US20160230198A1

  公开（公告）日：2016-08-11

  Microorganisms and methods are provided for biological synthesis of methylmalonic acid and derivatives thereof. Engineered microorganisms such as bacteria, yeast, and fungi are configured to produce or overproduce methylmalonic acid and/or derivatives thereof. Methods involve the use of such engineered microorganisms to produce methylmalonic acid and/or derivatives thereof from carbon sources. Methods may include production in a fermenter and optional purification of the product.
• METHOD FOR PRODUCING METHACRYLYL-CoA
  申请人：Mitsubishi Chemical Corporation

  公开号：US20190256880A1

  公开（公告）日：2019-08-22

  The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus Pseudomonas or Rhodococcus.