trans-Latanoprost Acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trans-Latanoprost Acid
• 英文别名: (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid
• 化学式: C₂₃H₃₄O₅
• 分子量: 390.5
• InChiKey: HNPFPERDNWXAGS-MIDWJBHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers
  申请人：Rozot Roger

  公开号：US20070092467A1

  公开（公告）日：2007-04-26

  Oxyacetamide compounds that are inhibitors of type-1 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and which have the formula (I), or salts and/or solvates thereof: are useful for inducing and/or stimulating the growth of human keratin fibers, e.g., human head hair and/or eyelashes, and/or for retarding the loss and/or increasing the density thereof and/or for caring for and/or making up such keratin fibers.

  氧乙酰胺类化合物是类型1 15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，其化学式为（I），或其盐和/或溶剂，可用于诱导和/或刺激人类角蛋白纤维（例如，人类头发和/或睫毛）的生长，或减缓其脱落和/或增加密度和/或护理和/或美化这些角蛋白纤维。
• Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
  申请人：Boulle Christophe

  公开号：US20070059260A1

  公开（公告）日：2007-03-15

  The benzyl-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate thereof: are useful active agents for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or preventing and/or limiting the depigmentation and/or bleaching thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for preventing and/or limiting the canities of human keratin fibers.

  苯甲基-1,3-噻唑啉-2,4-二酮化合物具有结构式(I)，或其盐和/或溶剂化物：对于促进和/或诱导和/或刺激角蛋白质材料的色素沉淀和/或预防和/或限制其脱色和/或漂白非常有用，特别是对于人类头发、胡须、小胡子、眼睫毛和眉毛的色素沉淀，优越地是对于预防和/或限制人类角蛋白纤维的白发的活性剂。
• Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers
  申请人：Boulle Christophe

  公开号：US20070065472A1

  公开（公告）日：2007-03-22

  The benzyl-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate thereof; are useful active agents for inducing and/or stimulating the growth of mammalian keratin fibers and/or reducing the loss and/or increasing the density thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for caring for or making up the hair or the eyelashes.

  苯甲基-1,3-噻唑啉-2,4-二酮化合物具有结构式（I），或其盐和/或溶剂化物；对于诱导和/或刺激哺乳动物角蛋白纤维的生长和/或减少其流失和/或增加密度，特别是人类头发、胡须、小胡子、睫毛和眉毛，具有有益作用，是护理或化妆头发或睫毛的有效活性剂。
• Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers
  申请人：Boulle Christophe

  公开号：US20070059265A1

  公开（公告）日：2007-03-15

  The benzylidene-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate and/or isomer thereof: are useful active agents for inducing and/or stimulating the growth of mammalian keratin fibers and/or reducing the loss and/or increasing the density thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for caring for or making up the hair or the eyelashes.

  苯甲醛基-1,3-噻唑啉-2,4-二酮化合物具有结构式（I），或其盐和/或溶剂和/或异构体：对于诱导和/或刺激哺乳动物角蛋白纤维的生长和/或减少其脱落和/或增加密度特别是人类头发，胡须，小胡子，睫毛和眉毛，具有有益的活性成分，可用于护理或化妆头发或睫毛。
• Benzylidene-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
  申请人：Boulle Christophe

  公开号：US20070071699A1

  公开（公告）日：2007-03-29

  The benzylidene-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate and/or isomer thereof: are useful active agents for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or preventing and/or limiting the depigmentation and/or bleaching thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for preventing and/or limiting the canities of human keratin fibers.

  具有结构式（I）或其盐和/或溶剂和/或异构体的苯甲醛基-1,3-噻唑啉-2,4-二酮化合物是促进和/或诱导和/或刺激角蛋白质材料的色素沉淀和/或预防和/或限制其褪色和漂白的有用活性剂，特别是人类头发、胡须、胡子、睫毛和眉毛，优点是预防和/或限制人类角蛋白质纤维的白发。