3'-(4-oxoquinazolin-3-yl)spiro[1H-indole-3,5'-oxolane]-2,2'-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3'-(4-oxoquinazolin-3-yl)spiro[1H-indole-3,5'-oxolane]-2,2'-dione
• 化学式: C₁₉H₁₃N₃O₄
• 分子量: 347.3
• InChiKey: WXXWBNXZGRMTHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRAZINOQUINAZOLINONE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY AND USES THEREOF
  申请人：Universidade do Porto

  公开号：EP3313406A1

  公开（公告）日：2018-05-02
• PYRAZINOQUINAZOLINONE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY, METHODS AND USES THEREOF
  申请人：UNIVERSIDADE DO PORTO

  公开号：US20180185370A1

  公开（公告）日：2018-07-05

  The present disclosure relates to compounds and compositions displaying antibacterial activity, particularly against Gram-positive bacteria. The compounds comprise a class of pyrazinoquinazolinone derivatives, including neofiscalin A and fiscalin C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The present disclosure further relates to methods for treating a patient with a bacterial infection with the disclosed compounds and compositions.
• [EN] PYRAZINOQUINAZOLINONE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY AND USES THEREOF<br/>[FR] DÉRIVÉS DE PYRAZINOQUINAZOLINONE AVEC ACTIVITÉ ANTIBACTÉRIENNE ET UTILISATIONS CORRESPONDANTES
  申请人：UNIV DO PORTO

  公开号：WO2016207830A1

  公开（公告）日：2016-12-29

  Pyrazinoquinazolinone derivatives with antibacterial activity, methods and uses thereof The present solution relates to medical compounds of formula I wherein R1, R2, R3 and R4 are independently selected from the following list: H, C1-C10 alkyl, C2-C10 alkenyl, C1-C10 aryl; provided that R1 is equal to R3 or, R3 is equal to R4 and R2 is selected from the following list: C1-C10 alkyl; or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, for use in the treatment of bacterial infections. The disclosure relates to pyrazinoquinazolinone derivatives, in particular neofiscalin A and fiscalin C, with antibacterial activity, namely against Gram-positive bacteria.