[EN] ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF<br/>[FR] INHIBITEURS D'ALK5, CONJUGUÉS ET LEURS UTILISATIONS
申请人:SILVERBACK THERAPEUTICS INC
公开号:WO2022076905A1
公开(公告)日:2022-04-14
ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein. The disclosed compounds and conjugates are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5.
本文披露了用于治疗疾病(如癌症)的ALK5抑制剂化合物、结合物和制药组合物。此外,本文还描述了与抗体构造物结合的化合物。所披露的化合物和结合物可用于治疗癌症和纤维化以及调节ALK5等方面。