2-amino-4-(ethylazaniumyl)butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-4-(ethylazaniumyl)butanoate
• 化学式: C6H14N2O2
• mdl: MFCD13372530
• 分子量: 146.19
• InChiKey: XEPKOIOJGLMVRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Cyclodextrin-Containing Polymers and Uses Thereof
  申请人：Gnaim Jallal M.

  公开号：US20080275139A1

  公开（公告）日：2008-11-06

  The invention provides a cyclodextrin-containing polymer comprising one or more cyclodextrin residues. The polymer is selected from a peptide, a polypeptide, an oligonucleotide or a polynucleotide or a mixture thereof. The peptide or polypeptide has at least one amino acid residue containing a functional side group and at least one of the cyclodextrin residues is covalently linked to the functional side group of the amino acid residue of said peptide or polypeptide or to the sugar moiety of a nucleotide residue of the oligonucleotide or polynucleotide.

  该发明提供了一种含有环糊精的聚合物，包括一个或多个环糊精残基。该聚合物选自肽、多肽、寡核苷酸或多核苷酸或其混合物。所述肽或多肽至少含有一个含有功能侧基的氨基酸残基，并且至少一个环糊精残基与所述肽或多肽的氨基酸残基的功能侧基或寡核苷酸或多核苷酸的核苷酸残基的糖基共价连接。
• TARGETING CONJUGATES COMPRISING ACTIVE AGENTS ENCAPSULATED IN CYCLODEXTRIN-CONTAINING POLYMERS
  申请人：Gnaim Jallal M.

  公开号：US20100226987A1

  公开（公告）日：2010-09-09

  A targeting conjugate is provided comprising an active agent, one or more residues of a cyclodextrin (CD)-containing polymer and a biorecognition molecule. The polymer is preferably a peptide or a polypeptide comprising at least one amino acid residue containing a functional side group to which at least one of the CD residues is linked covalently; the biorecognition molecule is covalently bonded directly or via a spacer to the polymer backbone of the CD-containing polymer; and the active agent is noncovalently encapsulated within the cavity of the cyclodextrin residues and/or entrapped within the polymer matrix of the CD-containing polymer.

  提供了一种靶向共轭物，包括活性剂、一个或多个含有环糊精（CD）的聚合物残基和生物识别分子。该聚合物最好是肽或多肽，包括至少一个氨基酸残基，其含有一个功能性侧基，至少一个CD残基与之共价连接；生物识别分子通过空间连接或直接与CD含聚合物的聚合物骨架共价键合；活性剂非共价地包装在环糊精残基的空腔内和/或被CD含聚合物的聚合物基质所包裹。