2-[[2-[(2-amino-3-phenylpropanoyl)amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneazaniumyl)pentanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-[(2-amino-3-phenylpropanoyl)amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneazaniumyl)pentanoate
• 化学式: C21H34N6O4
• 分子量: 434.5
• InChiKey: XMQSOOJRRVEHRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  186
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Method for accelerated healing of burn wounds
  申请人：PVP LABS PTE. LTD.

  公开号：US20210161993A1

  公开（公告）日：2021-06-03

  There is proposed a method for accelerated healing of a burn wound by reducing thermally-induced oedema and hyperemia, normalizing a neutrophil to lymphocyte ratio, stimulating formation of fibrous components in wound-induced scar tissue. The method includes aseptic preparation of a formulation consisting of an active ingredient being hexapeptide tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine (0.02-0.5 weight %), and at least one pharmaceutically acceptable excipient making up the rest, sterile fill-finishing the formulation, quality control thereof, and noninvasive local application of the formulation after thermal injury for accelerated healing of the burn wound, as a first-aid treatment and in subsequent therapy thereof. In a preferred embodiment, the formulation is provided in the form of solution, and the pharmaceutically acceptable excipient is purified water. In another preferred embodiment, the formulation is provided in the form of gel and the at least one excipient consists of hydroxyethyl cellulose 2.5-3%, potassium sorbate 2-3% and purified water up to 100%.