oxacycloheneicosan-2-one | 31844-01-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: oxacycloheneicosan-2-one
• 英文别名: 20-eicosanolide；oxacyclohenicosan-2-one
• CAS: 31844-01-6
• 化学式: C₂₀H₃₈O₂
• 分子量: 310.521
• InChiKey: XNVIXRMFBUDCLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  10-十一烯-1-醇 在 palladium on activated charcoal Grubbs catalyst first generation 、 氢气 作用下， 以 二氯甲烷 为溶剂， 生成 oxacycloheneicosan-2-one
  参考文献：
  名称：

  Conformationally Unbiased Macrocyclization Reactions by Ring Closing Metathesis

  摘要：

  DOI：

  10.1021/jo960733v

文献信息

• Inter- and Intramolecular Addition Reactions of Electron-Deficient Alkenes with Alkyl Radicals, Generated by SET-Photochemical Decarboxylation of Carboxylic Acids, Serve as a Mild and Efficient Method for the Preparation of γ-Amino Acids and Macrocyclic Lactones
  作者：Yasuharu Yoshimi、Miho Masuda、Tomoyuki Mizunashi、Keisuke Nishikawa、Kousuke Maeda、Nobumasa Koshida、Tatsuya Itou、Toshio Morita、Minoru Hatanaka

  DOI：10.1021/ol9019277

  日期：2009.10.15

  Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc γ-amino acids and macrocyclic lactones.

  由游离羧酸的SET光化学脱羧反应产生的烷基自由基的分子间和分子内加成反应是在温和条件下进行的，作为形成N -Bocγ-氨基酸和大环内酯的有效途径的一部分。
• Tishchenko reactions of aldehydes promoted by diisobutylaluminum hydride and its application to the macrocyclic lactone formation
  作者：Yung-Son Hon、Ying-Chieh Wong、Chun-Ping Chang、Cheng-Han Hsieh

  DOI：10.1016/j.tet.2007.08.074

  日期：2007.11

  Aliphatic aldehydes react with catalytic amount of Dibal-H in n-pentane to give the corresponding Tishchenko products in good to excellent yields. On contrary, α-silyloxy aldehydes give α-silyloxy ketones via Oppenauer oxidation under similar condition. Tishchenko reaction of ω-alkene aldehydes followed by RCM and hydrogenation affords a convenient method to prepare the 11–37 membered macrocyclic lactones

  脂肪醛与正戊烷中催化量的Dibal-H反应，以良好至极好的收率得到相应的季申科产品。相反，在类似条件下，α-甲硅烷氧基醛通过Oppenauer氧化生成α-甲硅烷氧基酮。ω-烯烃醛的Tishchenko反应，然后进行RCM和氢化提供了一种方便的方法来制备11-37元大环内酯。
• Radical Photocyclization Route for Macrocyclic Lactone Ring Expansion and Conversion to Macrocyclic Lactams and Ketones
  作者：Keisuke Nishikawa、Yasuharu Yoshimi、Kousuke Maeda、Toshio Morita、Ichiro Takahashi、Tatsuya Itou、Sho Inagaki、Minoru Hatanaka

  DOI：10.1021/jo3024126

  日期：2013.1.18

  two-carbon elongated macrocyclic lactones via decarboxylation. Similar photoreactions of carboxylic acid tethered acryl amide or α,β-unsaturated ketone moieties, which were also prepared starting from the macrocyclic lactones, produced macrocyclic lactams or ketones, respectively. The simple approach can be readily applied to the preparation of a variety of macrocyclic lactones, lactams, and ketones with

  已经发现了一种新的合成大环内酯，内酰胺和酮的方法，该方法利用了含有束缚的羧酸和α，β-不饱和羰基部分的底物的光诱导的分子内自由基环化反应。由大环内酯开始制备的羧酸系链丙烯酸酯的光环化，通过脱羧作用得到了两个碳的长链大环内酯。羧酸束缚的丙烯酰胺或α，β-不饱和酮部分的类似光反应，也从大环内酯开始制备，分别产生大环内酰胺或酮。简单的方法可以很容易地应用于制备各种具有可调环大小的大环内酯，内酰胺和酮。
• ANTISTATIC RESIN COMPOSITION
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP2460859A1

  公开（公告）日：2012-06-06

  An antistatic resin composition is provided, from which a thermoplastic resin molded article having a sufficient permanent antistatic property without impairing an excellent mechanical property or a good appearance of the molded article, even in a case that the content of an antistatic agent contained in the composition is less than that in a conventional composition, is provided. The antistatic resin composition contains an antistatic agent (A) and a thermoplastic resin (B)" in which a melt viscosity ratio of the thermoplastic resin (B) to the antistatic agent (A) at 220°C is 0.5-5 and an absolute value of a difference between solubility parameters (SPs) of the antistatic agent (A) and the thermoplastic resin (B) is 1.0-3.0. The antistatic resin molded article is obtained by molding the antistatic resin composition.

  本发明提供了一种抗静电树脂组合物，由该组合物制成的热塑性树脂模塑品具有足够的永久抗静电性能，即使在该组合物所含抗静电剂的含量低于常规组合物的情况下，也不会影响模塑品的优异机械性能或良好外观。抗静电树脂组合物包含抗静电剂（A）和热塑性树脂（B）"，其中热塑性树脂（B）与抗静电剂（A）在 220°C 时的熔融粘度比为 0.5-5，抗静电剂（A）和热塑性树脂（B）的溶解度参数（SP）之差的绝对值为 1.0-3.0。通过模塑抗静电树脂组合物可以获得抗静电树脂模塑制品。
• Studies on the conformational mobility of arachidonic acid. Facile macrolactonization of 20-hydroxyarachidonic acid.
  作者：E.J. Corey、Sadahiko Iguchi、John O. Albright、Biswanath De

  DOI：10.1016/s0040-4039(00)81320-9

  日期：1983.1