(1S,2S,3R,4R)-3-((S)-1-Acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1S,2S,3R,4R)-3-((S)-1-Acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid
• 英文别名: 3-(1-acetamido-2-ethylbutyl)-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid
• 化学式: C₁₅H₂₈N₄O₄
• 分子量: 328.41
• InChiKey: XRQDFNLINLXZLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Antiviral treatments
  申请人：BIOCRYST PHARMACEUTICALS

  公开号：US10391075B2

  公开（公告）日：2019-08-27

  The invention provides unit dosage forms, kits, and methods useful for treating viral infections.

  本发明提供了用于治疗病毒感染的单位剂型、试剂盒和方法。
• SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS
  申请人：BIOCRYST PHARMACEUTICALS INC.

  公开号：EP1040094B9

  公开（公告）日：2015-09-09
• Intramuscular antiviral treatments
  申请人：Babu Yarlagadda S.

  公开号：US20070244193A1

  公开（公告）日：2007-10-18

  The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
• INTRAMUSCULAR ANTIVIRAL TREATMENTS
  申请人：Babu Yarlagadda S.

  公开号：US20110015264A1

  公开（公告）日：2011-01-20

  The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
• FORMULATIONS FOR ENHANCED BIOAVAILABILITY OF ORALLY ADMINISTERED POLAR AGENTS
  申请人：Holmes Eric

  公开号：US20110206764A1

  公开（公告）日：2011-08-25

  A composition is described having improved oral permeability of polar agents such as neuraminidase inhibitors. The composition includes one or more polar agents and one or more permeability enhancers such that the composition increases the amount of the polar agent capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 Cell membrane in the absence of the permeability enhancer. Oral dosage forms including the composition, and methods of treating or preventing influenza infection are also provided.