1-Fluoro-3-phenylmethoxypropan-2-one | 151028-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Fluoro-3-phenylmethoxypropan-2-one
• CAS: 151028-28-3
• 化学式: C₁₀H₁₁FO₂
• 分子量: 182.195
• InChiKey: KHPREJTZIAMYSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Fluoro-3-phenylmethoxypropan-2-one 在 盐酸 、 ammonium chloride 、 methyloxirane 作用下， 以 水 为溶剂， 反应 24.0h， 生成 α-(monofluoromethyl) serine
  参考文献：
  名称：

  A versatile entry into the synthesis of α-(monofluoromethyl) amino acids : Preparation of α-(monofluoromethyl) serine and (E)-dehydro-α-(monofluoromethyl) ornithine.

  摘要：

  A new entry to the synthesis of alpha-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an alpha-(monofluoromethyl) ketone. As an example, alpha-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-alpha-(monofluromethyl ornithine.

  DOI：

  10.1016/s0040-4039(00)74090-1
• 作为产物：
  描述：

  苄基缩水甘油醚 在 草酰氯 、 potassium hydrogen difluoride 、 二甲基亚砜 、 三乙胺 作用下， 以 various solvent(s) 为溶剂， 反应 3.0h， 生成 1-Fluoro-3-phenylmethoxypropan-2-one
  参考文献：
  名称：

  A versatile entry into the synthesis of α-(monofluoromethyl) amino acids : Preparation of α-(monofluoromethyl) serine and (E)-dehydro-α-(monofluoromethyl) ornithine.

  摘要：

  A new entry to the synthesis of alpha-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an alpha-(monofluoromethyl) ketone. As an example, alpha-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-alpha-(monofluromethyl ornithine.

  DOI：

  10.1016/s0040-4039(00)74090-1

文献信息

• A versatile entry into the synthesis of α-(monofluoromethyl) amino acids : Preparation of α-(monofluoromethyl) serine and (E)-dehydro-α-(monofluoromethyl) ornithine.
  作者：Luc Van Hijfte、Véronique Heydt、Michael Kolb

  DOI：10.1016/s0040-4039(00)74090-1

  日期：1993.7

  A new entry to the synthesis of alpha-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an alpha-(monofluoromethyl) ketone. As an example, alpha-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-alpha-(monofluromethyl ornithine.