Fuchsin | 3248-93-9

• 物质功能分类: 染料及颜料 - 染料 - 溶剂染料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Fuchsin
• 英文别名: 4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline；4-[(4-aminophenyl)-(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]aniline
• CAS: 3248-93-9
• 化学式: C₂₀H₁₉N₃
• 分子量: 301.391
• InChiKey: YDCMWLQSPFTWCS-UHFFFAOYSA-N

物化性质

• 熔点：
  268-270°C decomposes
• 沸点：
  432.52°C (rough estimate)
• 密度：
  1.0962 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  75.9
• 氢给体数：
  3
• 氢受体数：
  3

ADMET

毒理性

• 解毒与急救

在处理被阳离子染料污染的眼睛时，急救措施包括大量冲洗、机械去除颗粒，如果嵌入彩色铅笔可能需要手术探查和小心去除颗粒。/阳离子染料/

IN TREATMENT OF EYES CONTAMINATED WITH CATIONIC DYES, FIRST AID MEASURES... INCLUDES COPIOUS IRRIGATION, MECHANICAL REMOVAL OF PARTICLES, & IN CASE OF IMBEDDED COLORED PENCIL MAY NECESSITATE SURGICAL EXPLORATION & CAREFUL REMOVAL OF PARTICLES. /CATIONIC DYES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

85名已知从事品红色制造业的男性中...有5例膀胱癌。其中3例记录为死于膀胱癌，而预期只有0.13例（相对风险=23.0；P小于0.005）。/品红色/

OF 85 MEN KNOWN TO HAVE BEEN ENGAGED IN MANUFACTURING MAGENTA...THERE WERE 5 CASES OF BLADDER CANCER. THREE OF THESE WERE RECORDED AS DYING OF BLADDER CANCER, WHEREAS ONLY 0.13 CASES WOULD HAVE BEEN EXPECTED (RELATIVE RISK= 23.0; P LESS THAN 0.005). /MAGENTA/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

将10毫克副品红作为1%溶液皮下注射每周一次...进入20只BD III大白鼠。首次局部肉瘤...在300天时，总剂量为370毫克染料。总共7个肉瘤...在12只大鼠出现第一个肿瘤后存活，与这些大鼠自发肉瘤发生率不到5%相比。

...INJECTED 10 MG PARA-MAGENTA AS 1% SOLN SC WEEKLY...INTO 20 BD III RATS. FIRST LOCAL SARCOMA...@ 300 DAYS, AFTER TOTAL DOSE OF 370 MG OF DYE. TOTAL OF 7 SARCOMAS...IN 12 RATS SURVIVING AFTER APPEARANCE OF FIRST TUMOR, COMPARED TO SPONTANEOUS INCIDENCE OF SARCOMAS IN THESE RATS OF LESS THAN 5%.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

每周通过胃内灌注给予60只实验鼠12毫克溶于花生油的品红色染料，持续52周（总剂量为624毫克）。尸检时发现染料已染色组织，21只实验动物中有4个淋巴瘤和1个肝细胞瘤，18只对照中有5个淋巴瘤。

...12 MG MAGENTA IN ARACHIS OIL PER WK WAS GIVEN TO 60 STOCK MICE BY GASTRIC INSTILLATION FOR 52 WK (TOTAL DOSE, 624 MG). DYE WAS FOUND TO HAVE STAINED TISSUES @ AUTOPSY...4 LYMPHOMAS & 1 HEPATOMA IN 21 TEST ANIMALS, & 5 LYMPHOMAS WERE FOUND IN 18 CONTROLS... /MAGENTA/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

阳离子染料众所周知会与核酸结合。/阳离子染料/

CATIONIC DYES ARE WELL KNOWN TO BIND TO NUCLEIC ACIDS. /CATIONIC DYES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

阳离子染料似乎具有氮原子的特殊属性，它是负责颜色的共振系统的一部分，并且似乎与强烈结合到角膜粘蛋白的羧基的倾向有关。/阳离子染料/

CATIONIC DYES APPEAR TO HAVE SPECIAL ATTRIBUTE OF NITROGEN ATOM WHICH IS PART OF RESONANT SYSTEM RESPONSIBLE FOR COLOR, & WHICH APPEARS TO BE ASSOC WITH PROPENSITY TO VERY STRONG BINDING TO CARBOXYL GROUPS OF CORNEAL MUCOPROTEINS. /CATIONIC DYES/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1
• 海关编码：
  2925290090

文献信息

• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Hong Rui

  公开号：US20130122516A1

  公开（公告）日：2013-05-16

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
• US9291597B2
  申请人：——

  公开号：US9291597B2

  公开（公告）日：2016-03-22