Confertifolin | 857216-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: Confertifolin
• 英文别名: Confertifoline；6,6,9a-trimethyl-4,5,5a,7,8,9-hexahydro-1H-benzo[e][2]benzofuran-3-one
• CAS: 857216-75-2
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: ZERYGJQXPPRRCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PERSONAL CARE ARTICLE AND METHOD FOR INHIBITING ATTACHMENT OF YEAST TO SKIN
  申请人：KIMBERLY-CLARK WORLDWIDE, INC.

  公开号：EP1509181A1

  公开（公告）日：2005-03-02
• [EN] PERSONAL CARE ARTICLE AND METHOD FOR INHIBITING ATTACHMENT OF YEAST TO SKIN<br/>[FR] ARTICLE DE SOIN PERSONNEL ET PROCEDE EMPECHANT L'ADHERENCE DES CHAMPIGNONS A LA PEAU
  申请人：KIMBERLY CLARK CO

  公开号：WO2003101356A1

  公开（公告）日：2003-12-11

  A personal care article including an isoprenoid compound, and a method of inhibiting attachment of pathogenic fungi to skin using an isoprenoid compound in combination with a personal care article. The isopreniod compound may be farnesol, which is particularly effective against the pathogenic yeast Candida albicans.
• [EN] COMPOSITIONS AND METHODS OF TREATMENT COMPRISING PLANT EXTRACTS<br/>[FR] COMPOSITIONS ET METHODES DE TRAITEMENT AU MOYEN D'EXTRAITS DE PLANTES
  申请人：GELSTAT CORP

  公开号：WO2004112819A1

  公开（公告）日：2004-12-29

  Methods of treating a disease associated with prolonged or excessive activation of NF-kB are provided, comprising administering a composition comprising at least one plant extract from a plant that is a source of sesquiterpene lactone, or a composition comprising a sesquiterpene lactone in an effective amount to a patient in need thereof. In a preferred embodiment, the plant extract is extracted from feverfew, and the sesquiterpene lactone is parthenolide. In a preferred embodiment of the invention, the composition is administered via a route that bypasses the GI tract. In another preferred embodiment of the invention, the composition is administered in an amount of active ingredient that is surprisingly low.