N-[(7-hydroxy-2-oxo-2H-chromen-4-yl)acetyl]glycine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(7-hydroxy-2-oxo-2H-chromen-4-yl)acetyl]glycine
• 英文别名: 2-[[2-(7-hydroxy-2-oxochromen-4-yl)acetyl]amino]acetic acid
• 化学式: C₁₃H₁₁NO₆
• 分子量: 277.23
• InChiKey: ZEPRIVLIMJJYGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SELECTIVE DRUG RELEASE FROM INTERNALIZED CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS
  申请人：Seagen Inc.

  公开号：US20210138077A1

  公开（公告）日：2021-05-13

  The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.