3-(3'-hydroxydecanoyloxy)decanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(3'-hydroxydecanoyloxy)decanoic acid
• 英文别名: 3-Hydroxydecanoyl-3-hydroxydecanoic acid；3-(3-hydroxydecanoyloxy)decanoic acid
• 化学式: C₂₀H₃₈O₅
• 分子量: 358.519
• InChiKey: ZFPAFAWFRTWCSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 硫酸 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 、 3-(3'-hydroxydecanoyloxy)decanoic acid
  参考文献：
  名称：

  Rhamnolipids as Platform Molecules for Production of Potential Anti-zoospore Agrochemicals

  摘要：

  Rhamnolipid biosurfactants have potential applications in the control of zoosporic plant pathogens. However, rhamnolipids have not been closely investigated for the anti-zoospore mechanism or for developing new anti-zoospore chemicals. In this study, RhL-1 and RhL-3 groups of rhamnolipids were used to generate the corresponding RhL-2 and RhL-4 groups and the free diacids. Conversion of RhL-3 to RhL-1 was also accomplished in vitro with cellobiase as the catalyst. The anti-zoospore effects of RhL-1RhL-4 and the diacids were investigated with zoospores of Phytophthora sojae. For RhL-1RhL-4, approximately 20, 30, 40, and 40 mg/L, respectively, were found to be the lowest concentrations required to stop movement of all zoospores, which indicates that the anti-zoospore effect remains strong even after RhL-1 and RhL-3 are hydrolyzed into RhL-2 and RhL-4. The free diacids required a significantly higher critical concentration of about 125 mg/L. Rhamnose can be obtained as a co-product.

  DOI：

  10.1021/acs.jafc.5b00033

文献信息

• Lipid production
  申请人：EVONIK OPERATIONS GMBH

  公开号：US11236372B2

  公开（公告）日：2022-02-01

  The present invention relates to at least one cell for producing at least one lipid with general formula II from at least one carbon substrate, wherein R1 and R2 independently of one another comprises identical or different organic radicals each with 5 to 13 carbon atoms, wherein the cell is a non-pathogenic cell that is genetically modified to increase the heterologous expression relative to the wild type cell of: an enzyme (E2) capable of converting 3-hydroxyalkanoyl-3-hydroxyalkanoyl-CoA/ACP or 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) and NDP-glucose into β-D-glucopyranosyl-3-hydroxyalkanoyl-3-hydroxyalkanoate.

  本发明涉及至少一种细胞，用于从至少一种碳基质中生产至少一种通式 II 的脂质、 其中 R1 和 R2 相互独立地由相同或不同的有机基组成，每个有机基含有 5 至 13 个碳原子、 其中细胞是一种非致病性细胞，经过基因修饰，相对于野生型细胞增加了以下物质的异源表达： 能够将 3-羟基烷酰-3-羟基烷酰-CoA/ACP 或 3-（3-羟基烷酰氧基）烷酸（HAA）和 NDP-葡萄糖转化为 β-D-吡喃葡萄糖基-3-羟基烷酰-3-羟基烷酸的酶（E2）。
• GLYCOLIPOPEPTIDE BIOSURFACTANTS
  申请人：Croda International PLC

  公开号：EP3440179B1

  公开（公告）日：2020-06-03
• LIPID PRODUCTION
  申请人：Evonik Operations GmbH

  公开号：EP3749680A1

  公开（公告）日：2020-12-16
• [EN] GLYCOLIPOPEPTIDE BIOSURFACTANTS<br/>[FR] BIOTENSIOACTIFS GLYCOPEPTIDIQUES
  申请人：CRODA INT PLC

  公开号：WO2017174748A2

  公开（公告）日：2017-10-12

  Surfactants based on a newly discovered class of compounds include a hydrophobic lipid oligomer covalently linked to a peptide or peptide-like chain and a carbohydrate moiety, and a serine- leucinol dipeptide linked to the lipid oligomer. Such surfactants can be used to create an oil-in- water or water-in-oil emulsion by mixing together a polar component; a non-polar component; and the surfactant. Biosurfactants of the newly discovered class can be made by isolating and culturing a microorganism which produces the biosurfactant, and then isolating the biosurfactant from the culture. A microorganism can be engineered to produce biosurfactant of this newly discovered class by expressing a set of heterologous genes involved in the biosynthesis of the biosurfactant in the microorganism.
• [EN] LIPID PRODUCTION<br/>[FR] PRODUCTION DE LIPIDES
  申请人：EVONIK DEGUSSA GMBH

  公开号：WO2019154984A1

  公开（公告）日：2019-08-15

  The present invention relates to at least one cell for producing at least one lipid with general formula (II) from at least one carbon substrate, wherein R1 and R2 independently of one another comprises identical or different organic radicals each with 5 to 13 carbon atoms, wherein the cell is a non-pathogenic cell that is genetically modified to increase the heterologous expression relative to the wild type cell of: - an enzyme (E2) capable of converting 3-hydroxyalkanoyl-3-hydroxyalkanoyl-CoA/ACP or 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) and NDP-glucose into β-D-glucopyranosyl-3-hydroxyalkanoyl-3-hydroxyalkanoate.