8-[2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-6-oxooctanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 8-[2-(2-Carboxyethyl)-5-hydroxy-3-oxocyclopentyl]-6-oxooctanoic acid
• 化学式: C₁₆H₂₄O₇
• 分子量: 328.36
• InChiKey: ZJAZCYLYLVCSNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Kit and method for measuring prostaglandin E-major urinary metabolite
  申请人：FUJIREBIO INC.

  公开号：US11169162B2

  公开（公告）日：2021-11-09

  Disclosed is a method of measuring the prostaglandin E main urinary metabolite (PGE-MUM), in which a mixture solution of a urine sample treated with alkali can directly be subjected to an antigen-antibody reaction system in an immunoassay of PGE-MUM, without neutralization and dilution followed by dispensation. The method of measuring PGE-MUM includes the steps of: a) mixing a urine sample with an alkaline aqueous solution, and b) subjecting the mixture solution resulting from a) to an immunoassay using a bicyclo PGE-MUM-immobilized or anti-bicyclo PGE-MUM antibody-immobilized solid phase to measure PGE-MUM in the urine sample, wherein the immunoassay is performed in a weakly-acidic basal buffer solution in the presence of a second pH buffering agent which exerts a buffering effect in the basic range and is different from the pH buffering agent contained in the basal buffer solution, and in the presence of a cationic surfactant.

  本发明公开了一种前列腺素 E 主要尿液代谢物（PGE-MUM）的测定方法，在该方法中，尿样经碱处理后的混合溶液可直接在抗原-抗体反应系统中进行 PGE-MUM 的免疫测定，无需中和稀释后再进行分装。测量 PGE-MUM 的方法包括以下步骤：a)将尿样与碱性水溶液混合，和 b)将 a)产生的混合溶液进行免疫测定，使用双环 PGE-MUM- 固定化或抗双环 PGE-MUM 抗体-固定化固相来测量尿样中的 PGE-MUM、其中，免疫测定是在弱酸性基础缓冲溶液中，在第二种 pH 缓冲剂的存在下进行的，第二种 pH 缓冲剂在碱性范围内发挥缓冲作用，与基础缓冲溶液中所含的 pH 缓冲剂不同，并且在阳离子表面活性剂的存在下进行。
• KIT AND METHOD FOR MEASURING PROSTAGLANDIN E-MAJOR URINARY METABOLITE
  申请人：FUJIREBIO INC.

  公开号：US20190072571A1

  公开（公告）日：2019-03-07

  Disclosed is a method of measuring the prostaglandin E main urinary metabolite (PGE-MUM), in which a mixture solution of a urine sample treated with alkali can directly be subjected to an antigen-antibody reaction system in an immunoassay of PGE-MUM, without neutralization and dilution followed by dispensation. The method of measuring PGE-MUM includes the steps of: a) mixing a urine sample with an alkaline aqueous solution, and b) subjecting the mixture solution resulting from a) to an immunoassay using a bicyclo PGE-MUM-immobilized or anti-bicyclo PGE-MUM antibody-immobilized solid phase to measure PGE-MUM in the urine sample, wherein the immunoassay is performed in a weakly-acidic basal buffer solution in the presence of a second pH buffering agent which exerts a buffering effect in the basic range and is different from the pH buffering agent contained in the basal buffer solution, and in the presence of a cationic surfactant.
• US4151199A
  申请人：——

  公开号：US4151199A

  公开（公告）日：1979-04-24