Methyl 2-ethyl-2,4-dimethyl-4-(oxiran-2-yl)pentanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 2-ethyl-2,4-dimethyl-4-(oxiran-2-yl)pentanoate
• 英文别名: methyl 2-ethyl-2,4-dimethyl-4-(oxiran-2-yl)pentanoate
• 化学式: C₁₂H₂₂O₃
• 分子量: 214.3
• InChiKey: ZJNDIOOPJMQNKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY AND METHODS FOR PREPARATION OF SAME
  申请人：Swain Philip A.

  公开号：US20100209449A1

  公开（公告）日：2010-08-19

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明揭示了能够通过在治疗组合物中给予而在体内引发抗卟胶原抗体的卟胶原载体共轭物。本发明还揭示了制备该共轭物和治疗组合物的方法。当卟胶原是药物滥用时，含有卟胶原载体共轭物的治疗组合物在治疗药物成瘾，特别是可卡因成瘾方面特别有用。本发明还揭示了使用针对本发明共轭物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗。