Acetyl coenzyme A sodium salt

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Acetyl coenzyme A sodium salt
• 英文别名: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] ethanethioate
• 化学式: C₂₃H₃₈N₇O₁₇P₃S
• 分子量: 809.6
• InChiKey: ZSLZBFCDCINBPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.6
• 重原子数：
  51
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  389
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• METHODS OF INCREASING THE CYTOTOXICITY OF CHEMOTHERAPEUTIC AGENTS WITH MULTISUBSTRATE INHIBITORS OF HISTONE, PROTEIN-LYS, POLYAMINE ACETYLATION, AND POLYAMINE METABOLISM
  申请人：Vanderbilt University

  公开号：US20160243063A1

  公开（公告）日：2016-08-25

  A method of treating cancer in a subject in need thereof, comprising administering to the subject a first amount of a compound of the HAT inhibitor of the following formula: wherein R is chosen from coenzyme A, (CH 2 ) 2 NHCO(CH 2 ) 2 NHCOR 2 ; (CH 2 ) 2 NHCOR 3 ; (CH 2 ) 2 NHCO(CH 2 ) 2 NHCOR 4 ; R 1 is H, NH 2 , NH, N, and R 1 can optionally cyclize with at least one other X 2 to form a C 3-8 membered ring containing C, O, S, or N; R 2 is chosen from alkyl, cycloalkyl, aryl, heteroaryl; R 3 is chosen from an alkyl, cycloalkyl, aryl, heteroaryl; R 4 is chosen from CH(OH)C(CH 3 ) 2 CH 2 )OCOR 2 ; X 1 is chosen from H or can cyclize with one other X 2 or R 1 to form a C 3-8 membered ring containing C, O, S, or N; and X 2 is chosen from C, N, NH, and can optionally cyclize with at least one other X 2 or R 1 to form a C 3-8 membered ring containing C, O, S, or N; or a pharmaceutically acceptable salt or hydrate thereof, thereby treating the cancer.

  一种治疗需要的患者体内癌症的方法，包括向患者投予以下式的HAT抑制剂化合物的第一量：其中R从辅酶A、(CH2)2NHCO( )2NHCOR2；( )2NHCOR3；( )2NHCO( )2NHCOR4中选择；R1为H、NH2、NH、N，且R1可以选择与至少另一个X2环化以形成含有C、O、S或N的C3-8环的环；R2从烷基、环烷基、芳基、杂环烷基中选择；R3从烷基、环烷基、芳基、杂环烷基中选择；R4从CH(OH)C(CH3)2 )OCOR2中选择；X1从H中选择，或者可以与另一个X2或R1环化以形成含有C、O、S或N的C3-8环；X2从C、N、NH中选择，或者可以选择与至少另一个X2或R1环化以形成含有C、O、S或N的C3-8环；或其药用盐或水合物，从而治疗癌症。
• TREATMENT OF CANCER
  申请人：MOORE Jerome

  公开号：US20120238601A1

  公开（公告）日：2012-09-20

  The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

  本发明提供了用于治疗癌症的物质组合物、试剂盒和使用它们的方法。特别地，本发明提供了通过抑制聚腺苷酸核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供这些组合物的配方和给药方式。
• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA TECHNOLOGIES S.a.r.l.

  公开号：US20150337275A1

  公开（公告）日：2015-11-26

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.

  本发明实施例涉及在分离酶存在或在表达这些酶的重组宿主细胞存在下，生物合成双或三功能C7烷的方法。这些双或三功能C7烷在生产尼龙-7、尼龙-7，x、尼龙-x，7和聚酯中作为中间体是有用的。
• RAPID DISCOVERY AND SCREENING OF ENZYME ACTIVITY USING MASS SPECTROMETRY
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150330992A1

  公开（公告）日：2015-11-19

  Described herein are methods, systems, and compositions for detecting enzyme activity. In some embodiments, the reaction product(s) are coupled with a mass tag, and the enzyme activity is determiner by analyzing the reaction product(s). The enzyme assays can be performed using mass spectrometry, for example nanostructure-initiator mass spectrometry (NIMS). Also described are methods, systems, and compositions for monitoring enzymatic degradation process of a substrate sample, for example a biomass.

  本文描述了检测酶活性的方法、系统和组合物。在某些实施例中，反应产物与质量标记偶联，通过分析反应产物来确定酶活性。酶测定可以使用质谱技术进行，例如纳米结构启动子质谱（NIMS）。还描述了监测底物样品（例如生物质）的酶降解过程的方法、系统和组合物。
• Malonate transporters
  申请人：CB Therapeutics, Inc.

  公开号：US11041002B1

  公开（公告）日：2021-06-22

  The methods and systems disclose enzymes that function to import malonic acid or malonates into a cell. The enzymes increase the output of precursor molecules by enriching certain pathways in the cell. The precursor molecules can be converted to cannabinoids. The enzymes are a family of proteins which have a majority of common alignments.

  这些方法和系统公开了具有将丙二酸或丙二酸盐输入细胞功能的酶。这些酶通过丰富细胞中的某些途径来增加前体分子的输出。前体分子可转化为大麻素。这些酶是一个蛋白质家族，有大多数共同的排列方式。