2-ethenyl-3,5-dimethylpyrazine | 157615-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-ethenyl-3,5-dimethylpyrazine
• 英文别名: 3,5-dimethyl-2-ethenylpyrazine；3,5-dimethyl-2-vinylpyrazine
• CAS: 157615-33-3
• 化学式: C₈H₁₀N₂
• mdl: MFCD18449161
• 分子量: 134.181
• InChiKey: ZUOLEJGELMNGPM-UHFFFAOYSA-N

物化性质

• 沸点：
  183.8±35.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、乙酸乙酯（微溶）
• LogP：
  1.503 (est)
• 保留指数：
  1078

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethenyl-3,5-dimethylpyrazine 在 臭氧 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以1.240 g的产率得到(3,5-dimethylpyrazin-2-yl)methanol
  参考文献：
  名称：

  [EN] AROMATIC RING COMPOUND
  [FR] COMPOSÉ À NOYAU AROMATIQUE

  摘要：

  本发明提供了一种具有GOAT抑制作用的化合物，该化合物用于预防或治疗肥胖等疾病，并具有优异的疗效。本发明的化合物由式(I)表示：其中每个符号如说明书中所定义，或其盐。

  公开号：

  WO2013125732A1
• 作为产物：
  描述：

  2,6-二甲基吡嗪 、 乙烯基溴化镁 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2-ethenyl-3,5-dimethylpyrazine
  参考文献：
  名称：

  Detection of Odor-Active Ethenylalkylpyrazines in Roasted Coffee

  摘要：

  In roasted Robusta coffee, two potent earthy smelling compounds were identified as 2-ethenyl-3,5-dimethylpyrazine and 2-ethenyl-3-ethyl-5-methylpyrazine by comparison of gas chromatography and mass spectrometry data with those of the corresponding reference substances. The odor threshold values (0.014 ng/L, air) of the new pyrazines were as low as those of 2-ethyl-3,5-dimethyl-and 2,3-diethyl-5-methylpyrazine. 3-Ethenyl-2-ethyl-5-methylpyrazine was also detected in coffee, and its odor threshold value was 8000 times higher than that of the 2-ethenyl-3-ethyl-5-methylpyrazine. After addition of HBr, the two ethenylethylmethylpyrazine. isomers were separated by capillary gas chromatography. The results indicate the presence of the two isomers in a 1:1 ratio in coffee.

  DOI：

  10.1021/jf9600824

文献信息

• Total chemical synthesis of 2-ethenyl-3,5-dimethylpyrazine and 3-ethenyl-2,5-dimethylpyrazine
  作者：Toshinari H Kurniadi、Rachid Bel Rhlid、Marcel-A Juillerat、Thierry Gefflaut、Jean Bolte、Ralf G Berger

  DOI：10.1016/s0040-4020(03)00948-7

  日期：2003.8

  2-ethenyl-3,5-dimethylpyrazine 1 and 3-ethenyl-2,5-dimethylpyrazine 2 were synthesized via a new chemical route. The key steps of the synthesis involve cyclocondenzation of 1-[bicyclo[2.2.1]5-hepten-2-yl]-1,2-propanedione and 1,2-propanediamine, aromatization of the resulting 5,6-dihydropyrazines, and subsequent Retro-Diels–Alder reaction to generate pyrazines 1 and 2. Pyrazine 1, a powerful odorant, was

  通过新的化学路线合成了香气化合物2-乙烯基-3,5-二甲基吡嗪1和3-乙烯基-2,5-二甲基吡嗪2。合成的关键步骤包括1- [双环[2.2.1] 5-庚-2-基] -1,2-丙二酮和1,2-丙二胺的环缩合，所得5,6-二氢吡嗪的芳构化，以及随后发生Retro-Diels-Alder反应，生成吡嗪1和2。当将内基-1- [双环[2.2.1] 5-庚-2-基] -1，1,2-丙二酮用作内衬时，可获得过量（8：2）的强效吡嗪1。
• AROMATIC RING COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150018547A1

  公开（公告）日：2015-01-15

  The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有GOAT抑制作用的化合物，该化合物可用于预防或治疗肥胖等疾病，并具有优越的疗效。该化合物由式(I)表示，其中每个符号如规范中所定义，或其盐。
• Aromatic ring compound
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US09238639B2

  公开（公告）日：2016-01-19

  The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供一种具有GOAT抑制作用的化合物，可用于预防或治疗肥胖等疾病，并具有优异的功效。本发明是由式（I）表示的化合物：其中每个符号如规范中所定义，或其盐。
• Arabinogalactan isolate from green and roasted coffee for food and delivery applications and process for its production
  申请人：NESTEC S.A.

  公开号：EP1600461A1

  公开（公告）日：2005-11-30

  The present invention refers to a process for extracting arabinogalactans from coffee comprising enzymatically hydrolysing whole or ground green or roasted coffee beans thereby obtaining an aqueous dispersion comprising partially hydrolysed coffee beans and arabinogalactans. Furthermore, the invention also encompasses products where the coffee derived arabinogalactans are used such as a glassy matix, pure soluble coffee and a beverage composition.

  本发明涉及一种从咖啡中提取阿拉伯半乳聚糖的工艺，该工艺包括对整粒或磨碎的绿咖啡豆或烘焙咖啡豆进行酶水解，从而获得一种包含部分水解咖啡豆和阿拉伯半乳聚糖的水分散液。此外，本发明还包括使用从咖啡中提取的阿拉伯半乳聚糖的产品，如玻璃毡、纯可溶咖啡和饮料组合物。
• Inert, glassy matrices for the stabilization of aroma in soluble coffee
  申请人：NESTEC S.A.

  公开号：EP1632135A1

  公开（公告）日：2006-03-08

  A glassy matrix for coffee aroma is provided in which the level of compounds which degrade aroma has been reduced, enabling the production of improved soluble coffee powder.

  提供了一种用于咖啡香味的玻璃基质，其中可降低香味的化合物含量，从而能够生产出更好的可溶性咖啡粉。