3,8a-dimethyl-5-methylidene-4H,4aH,6H,7H,8H-naphtho[2,3-b]furan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 3,8a-dimethyl-5-methylidene-4H,4aH,6H,7H,8H-naphtho[2,3-b]furan-2-one
• 英文别名: 3,8a-dimethyl-5-methylidene-4a,6,7,8-tetrahydro-4H-benzo[f][1]benzofuran-2-one
• 化学式: C₁₅H₁₈O₂
• 分子量: 230.3
• InChiKey: ZTVSGQPHMUYCRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• US9642832B2
  申请人：——

  公开号：US9642832B2

  公开（公告）日：2017-05-09
• [EN] TOPICAL COMPOSITION COMPRISING HYDROXAMIC ACID AND ATRACTYLENOLIDE<br/>[FR] COMPOSITION TOPIQUE COMPRENANT UN ACIDE HYDROXAMIQUE ET DE L'ATRACTYLÉNOLIDE
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021144326A1

  公开（公告）日：2021-07-22

  Disclosed is a topical composition comprising: (i) an antimicrobial active which is at least one of hydroxamic acids or hydroxamic acid derivatives; and (ii) an atractylenolide compound; wherein weight ratio of the amount of said atractylenolide compound to that of said antimicrobial active is at least 5:1. Also disclosed is a non-therapeutic method of providing topical antimicrobial benefit on a topical surface of a human or animal body comprising a step of applying a safe and effective amount of the topical antimicrobial composition.
• [EN] METHODS TO SENSITIZE CANCER CELLS TO IMMUNE ATTACK USING ATRACTYLENOLIDE I<br/>[FR] MÉTHODES POUR SENSIBILISER DES CELLULES CANCÉREUSES À UNE ATTAQUE IMMUNITAIRE À L'AIDE D'ATRACTYLÉNOLIDE I
  申请人：[en]THE TRUSTEES OF INDIANA UNIVERSITY

  公开号：WO2022125339A2

  公开（公告）日：2022-06-16

  The present disclosure relates to compositions and methods to induce or increase immunogenicity in cancerous cells comprising contacting the cancerous cells with atractylenolide I (ATT-I). In some embodiments, the methods include contacting the cancerous cells with ATT-I in combination with a cancer therapeutic agent.