2-Amyl-cyclopropancarbonsaeure | 13536-05-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amyl-cyclopropancarbonsaeure
• 英文别名: trans-2-Pentyl-cyclopropancarbonsaeure-(1)；cis-2-Pentylcyclopropanecarboxylic acid；2-pentylcyclopropane-1-carboxylic acid
• CAS: 13536-05-5
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: ZWABCHPDBORTSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
  申请人：Duke University

  公开号：US20130178520A1

  公开（公告）日：2013-07-11

  Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.

  本文描述了使用芳基环丙胺化合物治疗帕金森病的方法。
• Processes For The Preparation Of Optically Active Intermediates
  申请人：Mitsuda Masaru

  公开号：US20080071114A1

  公开（公告）日：2008-03-20

  This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl)cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1α,2α,3β(1S*,2R*),5β)]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.

  本发明涉及制备光学活性的2-(二取代芳基)环丙胺化合物和光学活性的2-(二取代芳基)环丙烷羧酰胺化合物的工艺，这些化合物是制备药物中间体的有用物质，特别是化合物[1S-(1α,2α,3β(1S*,2R*),5β)]-3-[7-[2-(3,4-二氟苯基)-环丙基]氨基]-5-(丙硫基)-3H-1,2,3-三唑[4,5-d]嘧啶-3-基)-5-(2-羟乙氧基)-环戊烷-1,2-二醇。
• METHODS OF REDUCING VIRULENCE IN BACTERIA
  申请人：Yang Ching-Hong

  公开号：US20120322769A1

  公开（公告）日：2012-12-20

  A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.

  一种减少细菌毒力的方法，包括至少一种GacS/GacA型系统、HrpX/HrpY型系统、T3SS型系统和Rsm型系统中的一种，该方法包括将细菌与本文所述化合物的有效量接触。
• Substituted arylcycloalkanes, compositions containing them and use thereof
  申请人：——

  公开号：US20030149072A1

  公开（公告）日：2003-08-07

  Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.

  被取代的芳基环烷烃、含有它们的组合物及其使用。本发明特别涉及具有治疗活性的取代芳基环烷烃，可用于肿瘤学等领域。
• Optically active 2-aryl cyclopropane carboxamide intermediates
  申请人：Astrazeneca AB

  公开号：EP2644591A1

  公开（公告）日：2013-10-02

  This invention relates to optically active 2-(disubstituted aryl) cyclopropane carboxamide derivatives which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1α, 2α, 3β (1S*,2R*),5β)]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.

  本发明涉及光学活性 2-（二取代芳基）环丙烷羧酰胺衍生物，该衍生物是制备药剂的有用中间体、特别是化合物[1S-(1α, 2α, 3β (1S*, 2R*), 5β)]-3-[7-[2-(3,4- 二氟苯基)-环丙基]氨基]-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基)-5-(2-羟基乙氧基)-环戊烷-1,2-二醇。