Intramolecullar alkylation of phenols. Part 4. Base-catalysed cyclisation of phenolic enones. Scope and limitations
作者:William S. Murphy、Sompong Wattanasin
DOI:10.1039/p19800001555
日期:——
The phenolicenones (4), (5), (8), (9), and (13) cyclise readily under acidic conditions. However, neither these nor the thin-substituted phenols (11a), (13a), (14a), and (15a) closed under basic conditions. Involvement of unfavourable equilibria is disproved. Comparison is made with related successful cyclisations of the saturated ketone (38) and aldehyde (39). Preliminary results suggest that strict
Facile Synthesis of Alkyl 1-Oxo-3-phenyl-1<i>H</i>-indene-2-carboxylate through Palladium-catalyzed Carboalkoxylation from 2-Bromo-3-phenylinden-1-ones
Palladium-catalyzed carboalkoxylation of 2-bromo-3-phenylindenones in various alcoholic solvents afforded diverse alkyl 1-oxo-3-phenyl-1H-indene-2-carboxylates in high yields.
Indenone derivative and pharmaceutical composition comprising same
申请人:Heo Jung Nyoung
公开号:US08877747B2
公开(公告)日:2014-11-04
An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.