Dimethylaminoethyl l-glutamine | 57418-09-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dimethylaminoethyl l-glutamine
• 英文别名: (2S)-5-amino-2-[2-(dimethylamino)ethylamino]-5-oxopentanoic acid
• CAS: 57418-09-4
• 化学式: C₉H₁₉N₃O₃
• 分子量: 217.27
• InChiKey: SIIATEVXRVOPNM-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  95.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• BALLOON CATHETER WITH POLYMERIC BALLOON HAVING A SURFACE MODIFIED BY A PHOTOACTIVATION REACTION AND METHOD OF MAKING
  申请人：D'Onofrio Simone

  公开号：US20140378897A1

  公开（公告）日：2014-12-25

  A balloon catheter, in particular a balloon catheter for angioplasty, the balloon having an inner or outer surface modified by means of a photoactivation reaction.

  一个气球导管，特别是用于血管成形术的气球导管，该气球通过光活化反应改性内部或外部表面。
• Implantabel stent prosthesis
  申请人：Boston Scientific Limited

  公开号：EP1757250A2

  公开（公告）日：2007-02-28

  The present invention relates to an implantable stent prosthesis for delivering a biologically active material to a patient. The prosthesis comprises a stent body having a surface adapted for exposure to body tissue of the patient and a coating disposed over at least a portion of the surface of the stent body. The coating comprises a biologically active material selected from the group consisting of anti-thrombogenic agents, anti-angiogenesis agents, anti-proliferative agents, growth factors, radiochemicals, and lovastatin, and a mixture of a first polymer and a second polymer, wherein the first polymer releases the biologically active material at a first rate and the second polymer releases the biologically active material at a second rate, wherein the second rate is slower than the first rate.

  本发明涉及一种向患者输送生物活性材料的可植入支架假体。该假体包括一个支架体，其表面适于暴露于患者的身体组织，支架体表面的至少一部分有一层涂层。涂层包括选自由抗血栓形成剂、抗血管生成剂、抗增殖剂、生长因子、放射化学物质和洛伐他汀组成的组的生物活性材料，以及第一聚合物和第二聚合物的混合物，其中第一聚合物以第一速率释放生物活性材料，第二聚合物以第二速率释放生物活性材料，其中第二速率慢于第一速率。
• Implantable stent prosthesis
  申请人：Boston Scientific Limited

  公开号：EP2292184A1

  公开（公告）日：2011-03-09

  The present invention relates to a stent comprising a stent body and a biologically active agent provided on at least a portion of said body. The biologically active agent is controllably released from said stent body over time, wherein said biologically active agent is provided in a mixture of a first polymer and a second polymer. The first polymer releases said agent at a first rate and the second polymer releases said agent at a second rate, wherein said first rate is faster than said second rate.

  本发明涉及一种支架，包括支架体和至少部分支架体上的生物活性剂。生物活性剂可控地随时间从所述支架体中释放，其中所述生物活性剂由第一种聚合物和第二种聚合物的混合物提供。第一种聚合物以第一速率释放所述药剂，第二种聚合物以第二速率释放所述药剂，其中第一速率快于第二速率。
• Stent with differential timing of abluminal and luminal release of a therapeutic agent
  申请人：Boston Scientific Limited

  公开号：EP2305323A2

  公开（公告）日：2011-04-06

  A stent designed for implantation into a blood vessel of a patient comprising: a tubular stent sidewall structure comprising a plurality of struts and openings in the sidewall structure; wherein at least one strut comprises an abluminal surface, a luminal surface opposite the abluminal surface, and side surfaces extending between the luminal and abluminal surfaces; a first coating composition disposed on the abluminal surface and luminal surface; and a second coating composition disposed on a portion of the first coating composition; characterized in that the portion is disposed either only on the abluminal surface and side surfaces or only on the abluminal surface; and when the stent is implanted, the second coating composition disposed on the abluminal surface faces the blood vessel.

  一种用于植入患者血管的支架，包括 管状支架侧壁结构，包括多个支杆和侧壁结构中的开口；其中至少一个支杆包括一个管腔表面、一个与管腔表面相对的管腔表面以及在管腔表面和管腔表面之间延伸的侧表面； 设置在腔体表面和腔体表面上的第一涂层组合物； 以及 第二涂层组合物，置于第一涂层组合物的一部分上；其特征在于 该部分 仅设置在腔体表面和侧表面上，或 仅设置在腔内表面；以及 当植入支架时，设置在消融面上的第二涂层组合物面向血管。
• Implantable medical devices and related methods of use
  申请人：Boston Scientific Scimed, Inc.

  公开号：US10232154B2

  公开（公告）日：2019-03-19

  A medical system may include an elongate member having a proximal end and a distal end, the elongate member being movable between a collapsed configuration and an expanded configuration, and a first therapeutic agent configured to treat a condition of the lung.

  医疗系统可包括一个具有近端和远端的细长部件，该细长部件可在折叠构型和展开构型之间移动，以及用于治疗肺部疾病的第一种治疗剂。